Project Grant R00HD112510
- The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse...
- The National Institute of Child Health and Human Development (NICHD) of the Department of Health and Human Services awarded North Carolina State University $673,394 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to decode epigenetic networks that orchestrate endometrial function. The project addresses molecular mechanisms underlying uterine dysfunction in recurrent implantation failure and recurrent pregnancy loss, which remain major...
- The National Institute of Child Health and Human Development awarded the University of Massachusetts $436,628 on May 25, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to define the dynamics and regulation of calcium/calmodulin-dependent protein kinase II gamma (CaMKIIγ) in egg activation. The recipient will monitor CaMKIIγ kinase activity in real-time using FRET biosensors (FRESCA-2 and FRESCA-3) during oocyte maturation, fertilization, and...
- The National Institute of Child Health and Human Development awarded California Institute of Technology $100,228 on December 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research identifying molecular and structural cues introduced at fertilization that influence early cell fate biases in the mammalian embryo. The research traces how sperm-derived components and the second polar body establish asymmetries as early as the 2-cell stage,...
- The National Institute of Child Health and Human Development awarded Yale University $132,022 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of histone H4 acetylation in mammalian embryogenesis and maternal aging. The research examines how epigenetic modifications, specifically H4K12ac (histone H4 lysine 12 acetylation), direct cellular transitions during early embryonic development and how dysregulation of these...
- The National Institute of Child Health and Human Development awarded Michigan State University $501,659 on June 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate calcium-dependent signaling in mammalian sperm metabolism during capacitation. The research examines how sperm activate and regulate changes in central carbon metabolic pathways to meet increased energy demands during ejaculation and capacitation. The project combines...
- The National Institute of Child Health and Human Development awarded The Regents of the University of California, San Francisco $123,147 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds research investigating granulosa-derived RNAs as targets for oocyte rejuvenation and age-related oocyte quality infertility. The project comprises three aims: interrogating the mechanism by which RNAs transfer from granulosa cells to...
- The National Institute of Child Health and Human Development awarded Yale University $1.396 million on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate centromere integrity and cytoskeletal function in oocyte aneuploidy and reproductive aging. The award funds research using mouse oocytes to analyze how centromere proteins (including CENP-A and CENP-C), centromeric DNA composition, and microtubule-associated proteins interact to...
- The National Institute of Child Health and Human Development awarded the University of North Carolina at Chapel Hill $1,172,712 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct a prospective cohort study examining the association between endometrial receptivity markers in menstrual effluent and fertility outcomes. The research will enroll 695 women from the community who are attempting to conceive and follow them for twelve...
- The National Institute of Child Health and Human Development awarded Yale University $456,999 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of acetyl-methyllysine in spermatogenic development. The research characterizes the distribution and regulation of acetyl-methyllysine (KACME), a histone modification combining lysine acetylation and methylation, during sperm development. Aim 1 applies custom anti-KACME...
The National Institute of Child Health and Human Development awarded East Carolina University $249,000 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate calcium-mediated mechanisms of metabolic and epigenetic changes at fertilization in mammals. The research uses mouse models to determine how abnormal calcium dynamics at fertilization impact embryonic epigenetic reprogramming and offspring development. The work addresses concerns that assisted reproductive technologies and conditions affecting mitochondrial function—such as obesity or advanced maternal age—can alter intracellular calcium oscillations and compromise embryonic developmental competence and offspring health. The three specific aims examine the impact of excess calcium on global chromatin accessibility and transcription profiles of early embryos, and identify underlying mechanisms mediated by histone-modifying enzymes including CREEBP and SIRT1. The research leverages genetically modified mouse models with altered calcium signaling at fertilization, developed during prior postdoctoral training, to isolate epigenetic changes driven by calcium dynamics without confounding effects of in vitro manipulation. Findings may inform standardization of culture media composition across assisted reproductive technology clinics and inform risk assessment for children conceived through these techniques or born to women with mitochondrial dysfunction. Performance occurs in North Carolina. The period of performance runs September 1, 2026, through August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/28/26 |