Rocky mountain cannabis research center
Active Project Grant Awarded Last action
- Award ID
- P50DA056408
- Recipient
-
The Regents Of The University Of Colorado UEI MW8JHK6ZYEX8 Part of The Regents Of The University Of Colorado
- Awarding agency
-
National Institute on Drug Abuse
National Institutes of Health, Department of Health and Human Services
- Obligated
- $16,750,881
Award facts
- Assistance listing
- 93.279 Drug Use and Addiction Research Programs
- Completion date 66% complete
- Place of performance
- Aurora, CO 80045, USA
Award details come from USAspending.gov.
Description
- Abstract
- Rocky mountain cannabis research center (RM-CRC) the united states has recently experienced enormous changes in the legal status and public acceptance of cannabis. Recreational and medical cannabis products that contain varying amounts of tetrahydrocannabinol (THC) and cannabidiol (CBD) are now widely available throughout north america. Despite these changes, research on the effects of THC and CBD has been lacking. The central goals of this research center of excellence application are to evaluate, in three research projects that span emerging, middle-aged, and older adults, how CBD affects the use of and subjective response to THC, and whether these effects are mediated by the endocannabinoid system (ECS) and associated lipids. To that end, the three research projects within the RM-CRC utilize research strategies that capitalize on three key innovations. First, the projects will employ mobile pharmacology laboratories to collect biological samples and assess the acute effects of THC and CBD on key neurocognitive and behavioral outcomes, endocannabinoids, and other lipids that interact with the ECS. Second, under the auspices of an FDA IND we hold for hemp-derived CBD, projects will randomly assign participants to CBD or placebo and will parametrically manipulate either the dose of CBD or whether the CBD product contains THC, to determine how hemp-derived CBD products may impact the effects of THC. Finally, the projects rely on newly designed assays within our cannabis research analytics core (CRAC) to measure cannabinoids, metabolites, terpenes, endocannabinoids, and other lipid mediators in blood samples. The data harmonization and analysis core (DHAC) will deploy a single-solution system to support data collection, harmonization across projects, and sharing of the data with the larger scientific community directly and via NIH approved repositories. The DHAC will also harmonize previously collected data (from 7 R01S, N=1359) and conduct advanced machine learning analyses of the relationships between THC and CBD blood levels, endocannabinoids and other lipid mediators, and behavioral data. The results will inform center-wide analyses of the harmonized P50 project data. Thus, the CRAC and DHAC provide the RM-CRC with significant added value that will allow the center to generate significant new knowledge with respect to how changes in the ECS and related lipids mediate the effects of THC and CBD across the lifespan. The RM-CRC is expected to be a significant resource to the field more broadly by providing other scientists access to data regarding CBD effects on psychiatric and health outcomes, cannabinoid, metabolite, and terpene blood levels, and 100+ endocannabinoids and related lipid mediators in approximately 2000 participants.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $2,793,251 | |
| Amendment | $2,803,466 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $2,803,466 | |
| Amendment | $2,803,466 | |
| Amendment | $2,773,616 | |
| Original award | $2,773,616 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| The Regents Of The University Of Colorado | $52,500 | |
| Emory University | $52,166 | |
| Georgia State University Research Foundation Inc. | $973,356 | |
| Emory University | $72,478 | |
| The Regents Of The University Of Colorado | $73,106 | |
| Emory University | $96,534 | |
| The Regents Of The University Of Colorado | $474,969 | |
| The Regents Of The University Of Colorado | $1,541,383 |
Quick answers
Who received award P50DA056408?
P50DA056408 was awarded to The Regents Of The University Of Colorado by National Institute on Drug Abuse (National Institutes of Health) on September 1, 2023.
How much is award P50DA056408 worth?
$16,750,881 has been obligated on P50DA056408.
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