Project Grant P01HL180318
- This $1,392,946 Project Grant awarded on July 20, 2025 by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research at the University of Pittsburgh to investigate the role of microbial-derived metabolites in driving airway hyperresponsiveness in obesity-associated asthma. The project aims to elucidate how dysregulated bile acid metabolism and gut dysbiosis instigate obesity-related asthma through alterations in the unfolded protein...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $288,986 to Biotherapeutics, Inc., a biotechnology company in Blacksburg, VA. The grant supports the development of a novel oral immunoregulatory therapeutic for the treatment of asthma. The key objectives are to: 1) Determine the safety profile and pharmacokinetics of the new therapeutic in rats, and 2) Characterize the therapeutic...
- This $387,116 Project Grant award from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) supports research at the University of South Florida to investigate the sensory neuronal mechanisms underlying the development of house dust mite-induced airway hyperreactivity, a key characteristic of asthma. The long-term goal is to define the neural mechanisms triggered by house dust mite exposure that lead to the development of airway...
- The federal Project Grant award, titled "MicroRNAs in Airway Smooth Muscle Function and Asthma," was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The $616,814 award, with a start date of January 15, 2025 and a completion date of November 30, 2028, supports research at the President and Fellows of Harvard College (Harvard T.H. Chan School of Public Health) to investigate the role of microRNAs in regulating...
- This Project Grant award for $355,935 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) supports the development of a novel, oral immunoregulatory therapeutic for the treatment of asthma. The primary objectives are to characterize the therapeutic efficacy and dosing regimen of the compound in mouse models of asthma, and to evaluate its ability to modulate immune function and suppress inflammation in human...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $771,750 to the Albert Einstein College of Medicine to conduct a cluster randomized controlled trial called "PRAGMATIC-S". The project aims to create an innovative interface between primary care and school-based programs to optimize the delivery of guideline-based asthma care to urban children with persistent or uncontrolled asthma. The award period runs...
- The federal Project Grant award titled "Targeting the Stromal Niche for Tissue-Resident Lymphocytes in Asthma" was provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The $636,843 award will fund research to characterize a targetable stromal factor that alters immune cell accumulation in the lung and define the downstream effects on airway epithelial cells. The project aims to leverage novel genetic tools, human...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $760,759 to the University of Illinois to examine the immunoregulatory role of a specific dendritic cell subset, CX3CR1+CDC2, in allergic lung inflammation. The project aims to characterize the anti-inflammatory functions of this cell population and its impact on regulatory T cell development and the resolution of allergic asthma symptoms. Through the use of novel...
- The National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), awarded a $189,000 Project Grant under CFDA #93.837 Cardiovascular Diseases Research program to the University of Colorado-Denver. The 2-year grant, with a period of performance from September 15, 2025 to August 31, 2027, will support research to investigate the role of outdoor air pollution and environmental allergens in driving treatment response in children with acute asthma...
- The University of New Mexico was awarded a $522,990 Project Grant under the National Institutes of Health (NIH) National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837). The grant, awarded on September 1, 2025, will support research to elucidate the mechanisms underlying the counter-regulation of allergic airway inflammation by regulating the responsiveness of Group 2 Innate Lymphoid Cells (ILC2s). The proposed studies aim to address the knowledge gap in...
This $2,456,717 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to exploit emerging ideas in G protein-coupled receptor biology and pharmacology to treat asthma. The award supports a highly collaborative research team at Thomas Jefferson University's Sidney Kimmel Medical College to pursue three key goals: 1) identify novel targets and targeting molecules involving G protein-coupled receptor regulation of airway smooth muscle contraction and proliferation; 2) delineate the mechanisms by which these novel targets/targeting molecules regulate these airway smooth muscle functions; and 3) establish the therapeutic utility of novel targeting molecules in in vivo models of asthma. The award period runs from September 20, 2025 through July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.5m | 9/16/25 |