Learning from remission and relapse in SLE

Active Project Grant Awarded Last action

Award ID
P01AI172523
Recipient
Awarding agency
Obligated
$11,608,223

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 50% complete
Place of performance
Manhasset, NY 11030, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Overview this program project is an exploration of patients with systemic lupus erythematosus who are in long term clinical remission on no corticosteroid or immunosuppressive medication. We will study blood immune cells at the single cell level exploring distribution of cellular subsets and transcriptional, epigenetic and proteomic profiles, as well as the repertoire of naive and memory B cells reactive with nuclear antigens. We will explore brain function in these patients to determine if there is ongoing inflammation in the central nervous system in some patients despite a lack of inflammation in the periphery. Given the now recognized interplay of the immune system and the brain, we will seek correlations between immune cell profile and brain function. As approximately 25% of patients in remission can be expected to relapse over 5 years, we will seek predictors of relapse. These studies should teach US about patient heterogeneity, novel states of immune or brain homeostasis, and predictors of sustained remission or flare.

Transactions

Action Obligated Date
Amendment $83,448
Amendment $132,967
Amendment $2,684,379
Amendment $90,908
Amendment $90,908
Amendment $132,967
Amendment $132,967
Amendment $2,678,601
Amendment $2,678,601
Original award $2,902,477

Subawards

Subrecipient Amount Awarded
University College London The overall goal of the project is to characterize the state of systemic immune activation in adult SLE patients with previously active disease who are in… $90,908
University Of California, LOS Angeles Learning from Remission and Relapse in SLE $141,480
University College London $91,863
Instituto Nacional De Ciencias Medicas Y Nutricion Salvador Zubiran $152,436
The Regents Of The University Of California. San Francisco $930,667
The Regents Of The University Of California. San Francisco $323,000
Albert Einstein College Of Medicine $150,109

Quick answers

Who received award P01AI172523?

P01AI172523 was awarded to The Feinstein Institutes For Medical Research by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on May 9, 2024.

How much is award P01AI172523 worth?

$11,608,223 has been obligated on P01AI172523.

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