Project Grant N629091612003

This $495,000 National Science Foundation project grant supports collaborative research at the University of Colorado Denver to explore the potential role of non-coding RNAs in encoding molecular memory. Funded under the Biological Sciences program (CFDA 47.074), the three-year award beginning May 1, 2023 will examine whether a simple form of memory known as behavioral sensitization can be stored by non-coding RNA. The principal investigators hypothesize that expression or post-transcriptional...

This $438,342 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to study the fundamental mechanisms by which ubiquitin ligases recognize and ubiquitinate substrates within protein complexes. The research focuses on understanding the role of the anaphase-promoting complex (APC) in regulating the composition of neuronal...

This National Science Foundation award provides $584,997 to the University of California, Los Angeles under the Biological Sciences federal grant program (CFDA 47.074) from May 1, 2023 through April 30, 2026. The funding supports collaborative research exploring the potential roles of non-coding RNAs in encoding memory. Specifically, the award will examine whether behavioral sensitization memory can be stored by non-coding RNA or induce downstream molecular changes that store memory in the...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,830,581 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to The Johns Hopkins University. The grant supports in-depth characterization of the mechanism of action of a new macrocycle molecule called RAPIREON, which selectively activates the nuclease activity of the IRE1 protein in the unfolded protein response (UPR) pathway....

The University of North Carolina at Chapel Hill (UNC-CH) received a $1,377,516 Project Grant from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to conduct cell-type-specific proteomic research on brain white matter. The 3-year project aims to define the molecular landscape of brain white matter with regional, temporal, cellular, and subcellular specificity, in both healthy mice and disease models. Researchers will leverage proximity-based...

This Project Grant award, valued at $481,250.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The goal is to enable unique forms of subcellular functional investigation in subtype- and...

This National Science Foundation project grant award of $600,000 supports research into the mechanisms underlying long-term memory storage at the University of California, Los Angeles from February 1, 2022 to January 31, 2025. The award is made under the Biological Sciences program (CFDA 47.074) to promote progress in the biological sciences. Specifically, the grant funds research investigating whether memories are stored through nuclear modifications in neurons rather than changes in...

This federal Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) provides $460,855 to New York University School of Medicine to investigate the cellular and circuit mechanisms by which acetylcholine (ACh) promotes associative learning in the primary somatosensory cortex. The key objectives are to: 1) use fluorescent ACh sensors and chemogenetic techniques to study the magnitude and time course of ACh release during different phases of an...

This Project Grant award from the National Science Foundation's Biological Sciences Program (CFDA 47.074) will provide $502,981 to the University of Richmond to explore the molecular mechanisms underlying the delivery of AMPA neurotransmitter receptors during the formation of memories. The project aims to identify novel proteins involved in this receptor trafficking process and describe key steps in the membrane fusion events that facilitate receptor insertion at neuronal synapses. This work...

The National Science Foundation Division of Emerging Frontiers awarded the University of North Carolina at Chapel Hill a $382,770 Project Grant under the Biological Sciences (47.074) federal grant program to conduct research titled "Functional Genomics of Spatial Memory" from January 1, 2022 to December 31, 2024. The Biological Sciences program aims to promote progress in the biological sciences and strengthen the nation's scientific enterprise through increasing knowledge and...