Project Grant K99HD120622
- The National Institute of Child Health and Human Development awarded Brigham & Women's Hospital Inc. $631,658 on June 5, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of caudate-putamen Kiss1 neurons in female minipuberty, reproductive maturation, and cognitive function. The award funds research characterizing a sexually dimorphic population of Kiss1/GnRH co-expressing neurons in the caudate putamen that appear to drive...
- The National Institute of Child Health and Human Development awarded Albany Medical College $164,000 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of AVPV KISS1 neurons in modulating female and male reproduction. The research addresses mechanisms controlling fertility through the hypothalamic-pituitary-gonadal axis. KISS1 neurons in the anteroventral periventricular nucleus are hypothesized to mediate...
- The National Institutes of Health Office of the Director awarded Beth Israel Deaconess Medical Center $2,074,796 on September 15, 2025, under Trans-NIH Research Support (CFDA 93.310) to investigate orexin neuropeptides and their role in menopausal symptom severity using a mouse model. The research examines how chronically low estradiol in postmenopausal states elevates orexin neuron activity in the hypothalamus, leading to increased sleep disruption and vasomotor responses such as hot flashes....
- The National Institute of Child Health and Human Development awarded The General Hospital Corporation (Massachusetts General Hospital) $538,173 on August 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, assistance type: Project Grant) to investigate the molecular mechanisms controlling developmental timing through NADH redox metabolism. The project uses a segmentation clock—a molecular oscillator whose period correlates with embryonic development...
- The National Institute of Child Health and Human Development awarded Boston University (Trustees of Boston University, doing business as Boston University Medical Campus) $702,577 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct a longitudinal study examining heat exposure, placental health, and adverse pregnancy outcomes. The research leverages an existing cohort of 610 pregnant women who attended prenatal visits at...
- The National Institute of Child Health and Human Development awarded New York University $237,660 on January 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate how sickness disrupts maternal brain circuits and caregiving behavior during the postpartum period. The research examines how acute inflammatory challenge—induced by lipopolysaccharide injection—alters neuropeptidergic circuits in the paraventricular nucleus of the...
- The National Institute of Child Health and Human Development awarded the University of California, Los Angeles $123,876 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support a K99/R00 career-development project grant investigating the neural basis of thermoregulatory adaptations during pregnancy. The award funds a candidate's specialized training in miniaturized microscopy to monitor calcium activity of individual neurons in the...
- The National Institute of Child Health and Human Development awarded Yale University $1.396 million on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate centromere integrity and cytoskeletal function in oocyte aneuploidy and reproductive aging. The award funds research using mouse oocytes to analyze how centromere proteins (including CENP-A and CENP-C), centromeric DNA composition, and microtubule-associated proteins interact to...
- The National Institute of Child Health and Human Development awarded the University of California, San Diego $650,472 on September 1, 2026, under the Child Health and Human Development Extramural Research Program (CFDA 93.865) to investigate how adrenergic signaling from brainstem norepinephrine neurons regulates reproductive neuroendocrine circuits in response to chronic psychosocial stress. The research addresses how stress impairs kisspeptin neuron function and downstream luteinizing...
- The National Institute of Child Health and Human Development awarded the University of South Florida $114,237 on June 5, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research dissecting estrogen receptor alpha (ERA) functions in anteroventral and periventricular medial preoptic area neurons co-expressing the long-form leptin receptor. The research examines how ERA signaling as a nuclear receptor and mRNA-binding protein—distinct from...
The National Institute of Child Health and Human Development awarded Beth Israel Deaconess Medical Center, Inc. $129,377 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate relationships between sexual behavior rhythms, core body temperature, and sleep in female mice and their implications for fertility. The research will identify brain circuits regulating female sexual behavior rhythms, determine whether mild cooling immediately after copulation affects embryo development, define critical temporal windows when core body temperature manipulations affect female fertility and early embryos, and test whether periconceptional warming rescues fertility deficits in female mice exposed to chronic shift work. The work addresses gaps in understanding how circadian clock misalignment—as occurs with shift work or jet lag—impacts female reproductive success, building on preliminary data in mice showing that core body temperature increases during the active phase of the estrous period and that mild reductions in core body temperature after copulation reduce pregnancy success. The period of performance runs from September 1, 2026, through August 31, 2028. Work is performed in Boston, Massachusetts. This is a project grant, classified as assistance funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $129.4k | 8/27/26 |