Project Grant K99EY037781
- Federal Grant Award Summary The Schepens Eye Research Institute, Inc. received a $1.79 million Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 1, 2025 through August 31, 2027. The award funds research to develop and validate non-invasive transpalpebral electrical stimulation (TPES) as a therapeutic treatment for diabetic keratopathy, a corneal nerve damage condition affecting individuals with diabetes. The research will...
- Federal Project Grant Award Summary New York University School of Medicine received a $285,498 Project Grant from the National Eye Institute (NEI) Vision Research program (CFDA 93.867), awarded September 30, 2025, with completion targeted for August 31, 2027. The award funds a research investigation into the mechanisms underlying corneal lens development using Drosophila (fruit fly) as a model organism to understand human corneal pathologies including myopia, hyperopia, astigmatism, and...
- Federal Grant Award Summary New York University School of Medicine received a $546,439 Project Grant from the National Eye Institute (NEI) Vision Research program (CFDA 93.867), effective April 15, 2026 through March 31, 2030. This award funds research to develop corneal stromal keratocyte modeling from human cornea organoids (HCOs) as a potential therapeutic approach to address corneal blindness caused by stromal scarring, infection, and keratoconus. The research leverages induced pluripotent...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant totaling $540,213 under the Vision Research program (CFDA 93.867) to investigate the fibrosis-immunity interface in corneal transplantation. Beginning August 1, 2025, and extending through July 31, 2030, this research program will deliver scientific findings aimed at improving corneal transplant survival rates by elucidating the mechanisms by which myofibroblasts...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a $260,661 Project Grant to The Schepens Eye Research Institute, Inc. for a three-year career development initiative spanning August 1, 2025, through July 31, 2028. The award supports Dr. Levi N. Kanu's mentored research program focused on developing nanomaterial-based growth factor delivery systems to improve therapeutic outcomes for corneal disease. The research plan...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded Massachusetts General Hospital a $643,357 Project Grant on June 15, 2026, to develop and validate a Brillouin microscopy-based imaging technology for direct measurement of corneal hydration. The primary deliverables include a combined Brillouin-optical coherence tomography (OCT) system capable of integrated functional and structural analysis of the cornea, along with...
- Federal Grant Award Summary The University of North Texas Health Science Center at Fort Worth received a $249,000 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 15, 2026, with a completion date of March 31, 2029. This award supports research aimed at developing non-surgical treatments for keratoconus, a progressive corneal disorder affecting approximately 1 in 500 to 2,000 Americans. The research focuses on inhibiting...
- Federal Grant Award Summary Tufts University School of Medicine received a $144,618 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 1, 2025, through March 31, 2028. The award funds research investigating fucosylation as a mediator of limbal stem cell (LSC) viability to develop novel therapeutic approaches for limbal stem cell deficiency (LSCD), a potentially blinding condition with limited treatment options. The research...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded The Ohio State University $433,125 on August 1, 2025, to investigate tissue factor (TF) as a potential biomarker and therapeutic target for corneal neovascularization (CNV). This two-year project, concluding July 31, 2027, addresses a significant unmet medical need, as CNV—the pathological growth of blood vessels in the cornea—is a common sequela of corneal diseases...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $527,987 Project Grant to the University of California, Los Angeles (UCLA) for the period May 1, 2026 through April 30, 2030 under the Vision Research program (CFDA 93.867). The award supports the development of an engineered, tunable biomimetic adhesive hydrogel platform designed to deliver mesenchymal stem cells (MSCs) to the cornea for regeneration and repair. The research addresses a critical bottleneck in corneal disease...
The National Eye Institute's Vision Research program (CFDA 93.867) awarded $132,837 to The Schepens Eye Research Institute, Inc. (July 1, 2026 – June 30, 2028) to investigate the pathophysiology of keratoconus and develop targeted therapeutic interventions. The research will produce scientific knowledge regarding hormonal dynamics and extracellular vesicle (EV) function in keratoconus progression through analysis of tear samples from affected and non-affected patients combined with a developed three-dimensional collagen hydrogel model of corneal epithelium and keratocytes. Specific deliverables include identification of signaling pathways involving matrix metalloproteinases (MMP-2/9) regulation, characterization of the functional roles of tear-derived EVs and their molecular constituents, and establishment of prognostic biomarkers to predict disease progression rates among keratoconus patients. The research outcomes will inform the development of topical therapeutic agents to mitigate hormone-mediated corneal thinning and collagen degradation. By elucidating the roles of follicle-stimulating hormone, luteinizing hormone, estrogen, and progesterone in keratoconus pathogenesis, this project addresses a critical gap in understanding why the progressive corneal ectasia typically manifests after puberty, may be exacerbated by pregnancy, and rarely progresses after menopause—ultimately contributing to improved clinical management and quality of life for patients with this vision-threatening condition.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $132.8k | 6/12/26 |