Project Grant K99CA299840
- The National Cancer Institute awarded Northwestern University $663,998 on June 15, 2026, for the Fit2ThriveMB project, which optimizes a digital physical activity promotion intervention for metastatic breast cancer patients. The project applies multiphase optimization strategy methodology to identify which intervention components or component combinations most effectively increase daily steps in metastatic breast cancer patients over a 12-week intervention period with a 12-week follow-up. The...
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $235,491 on May 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support research training and career development in cancer research. The award funds investigation into high-count monoclonal B-cell lymphocytosis (HC-MBL) and its relationship to mosaic chromosomal alterations, particularly deletions in chromosome 13q and trisomy 12. The research will examine phenotypic consequences of HC-MBL across two...
- The National Cancer Institute, within the Department of Health and Human Services, awarded Dana-Farber Cancer Institute, Inc. $718,275 on July 1, 2026, under the Cancer Biology Research program (CFDA 93.396) to investigate context-specific pathway dependencies for nuclear envelope proteins in brain cancer. The research addresses how nuclear envelope-associated proteins perform distinct biochemical functions across different cellular contexts in central nervous system cancers. The project uses an...
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $645,102 on July 1, 2026, under the Cancer Biology Research program (CFDA 93.396) to support research investigating the molecular mechanisms governing WEE1 kinase transition from CDK inhibitor to substrate in cell cycle control. The project addresses how WEE1 kinase shifts between functioning as an active enzyme and as a substrate for phosphorylation at the G2-to-M cell cycle checkpoint. The work focuses on the N-terminal...
- The National Cancer Institute awarded The MGH Institute of Health Professions, Inc. $696,498 on May 1, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to develop and optimize a multicomponent intervention for improving functional recovery and participation in life roles among breast cancer survivors. The research uses the Multiphase Optimization Strategy (MOST) framework to systematically test three remotely delivered intervention components: priority elicitation to...
- The National Cancer Institute, an office of the Department of Health and Human Services National Institutes of Health, awarded Dana-Farber Cancer Institute, Inc. $657,443 on September 1, 2026, under the Cancer Biology Research program (CFDA 93.396, Assistance Listing R01CA315392). The award funds structural and mechanistic studies of the RAS/RAF MAPKINASE pathway to achieve atomic-resolution understanding of how these proteins recognize and interact with one another and how these interactions...
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc., $144,035 on September 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support research dissecting transcription factor-mediated chromatin remodeling complex activities in human cancer. The funded work integrates biochemistry, structural biology, functional genomics, and chemical biology approaches to define how BAF (mammalian SWI/SNF) chromatin remodeling complexes are recruited by transcription...
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $606,749 on August 13, 2026, under the Cancer Biology Research program (CFDA 93.396) to investigate novel functions of cell cycle proteins in G1/S phase progression and cancer. The research examines the molecular roles of the cyclin B–CDK1 kinase complex in regulating cell cycle entry and DNA synthesis. Aim 1 uses mouse and human cells to identify the range of molecular functions played by cyclin B–CDK1 during G1/S phase....
- The National Cancer Institute, a component of the Department of Health and Human Services National Institutes of Health, awarded Dana-Farber Cancer Institute, Inc. $134,919 under the Cancer Research Manpower program (CFDA 93.398) on June 11, 2026. The award funds structure-function and mechanistic studies of the protein-O-mannosyl transferase (POMT) complex in pediatric low-grade gliomas driven by the KIAA1549:BRAF fusion. The research aims to determine high-resolution structures of the POMT...
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $230,388 on January 16, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support basic research training in cancer biology and immunotherapy. The award funds research interrogating the role of interferon gamma (IFNG) in promoting metastasis and immune evasion of triple negative breast cancer. The research comprises two aims: elucidating IFNG's role in immune evasion during triple negative breast cancer...
The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $168,960 on September 3, 2026, under the Cancer Research Manpower program (CFDA 93.398) to investigate the relationship between daily step count trajectories measured by wearable devices and patient-reported outcomes and recurrence-free survival in early breast cancer survivors. The research uses longitudinal data from wrist-worn actigraph devices deployed in the Breast Cancer Weight Loss (BWEL) trial, an NCI-funded phase III randomized trial of 3,180 women with stage II-III breast cancer and BMI ≥ 27 kg/m² testing the impact of supervised weight loss intervention on invasive disease-free survival. The study addresses a gap in evidence: prior research on physical activity and breast cancer outcomes relied on self-reported measures at single time points or small-scale controlled trials, whereas real-world wearable monitoring enables continuous collection of detailed longitudinal activity data. Step count serves as both a patient-facing goal-setting metric and a clinician-facing monitoring tool accessible to cancer survivors. Performance occurs in Boston, Massachusetts, with a completion date of August 31, 2028. The award is obligated at $168,960.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $169.0k | 9/2/26 |