Comparative assessment of P16/KI-67 dual staining technology in women living with HIV (compass-dust study)
Active Project Grant Awarded Last action
- Award ID
- K43TW011930
- Recipient
-
College Of Medicine, University Of Lagos UEI XYJ3LWJF87N5
- Awarding agency
-
Fogarty International Center
National Institutes of Health, Department of Health and Human Services
- Obligated
- $486,246
Award facts
- Assistance listing
- 93.989 International Research and Research Training
- Completion date 86% complete
- Funding agency
- National Cancer Institute National Institutes of Health, Department of Health and Human Services
- Place of performance
- Nigeria
Award details come from USAspending.gov.
Description
- Abstract
- This application presents a five-year career development and research program for an early career investigator from nigeria. The candidate, kehinde okunade, is a 2018 fogarty fellow through the hbnu FIC D43 training program and also a senior lecturer in obstetrics and gynecology at the college of medicine of the university of lagos in nigeria. The goals of his application are to use the protected time provided through the program to (1) build and strengthen mentoring relationships and skills transfer through regular interactions with mentors and CO-mentors; (2) acquire experiential skills in clinical epidemiologic research and be able to translate this to public health practice (3) conduct the rigorous research proposed in the application; (4) acquire skills in the design and conduct of end-to-end clinical trials; (5) establish research collaboration network and effectively coordinate multidisciplinary research projects, and (6) be able to write, secure, and manage grants to conduct studies as well as write manuscripts for publication in high-impact journals. The proposed research in the FIC K43 application, "comparative assessment of P16/KI-67 dual staining technology in women living with HIV (compass-dust)" is the first in sub-saharan africa (SSA) that aims to evaluate the performance of P16/KI-67 dual staining technology (dust) in cervical cancer screening among women living with HIV (wlhiv). In aim 1 and 2, using an intra-participant comparative study design, we will enrol n=300 sexually active wlhiv aged 25-65 years at two accredited adult HIV treatment centres in lagos, nigeria to compare the performance of dust to the currently used screening methods (PAP smear, HR-HPV DNA, or via testing) in detecting high-grade cervical intraepithelial neoplasia (CIN2/3). In aim 3, we will use a prospective cohort study design to enrol wlhiv (n=60) who are diagnosed as having low-grade CIN (CIN1) for a 6-monthly follow-up for 2 years to detect persistent CIN1 and progression of CIN1 to CIN2/3. The findings of this study will be of great public health significance for 2 reasons. First, they may provide evidence of the existence of a better performance screening method for the primary and triage detection of CIN2/3 in wlhiv. Secondly, we may demonstrate that this high-performance test can improve the long-term predictive accuracy of screening by extending the intervals between evaluations and thus decrease the overall cost and increase screening uptake in wlhiv. This application will build on the candidate's background experience and the expertise of his team of mentors and CO-mentors in nigeria and the US to achieve the training and research goals of this program. In the long- term, the proposed research and training activities will provide the candidate with a unique set of experiential skills that will enable him to transition to independence as a physician-scientist.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $5,227 | |
| Amendment | $97,353 | |
| Amendment | $95,184 | |
| Amendment | $4,454 | |
| Amendment | $93,550 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | -$91,699 | |
| Amendment | $91,699 | |
| Amendment | -$91,699 | |
| Amendment | $91,699 | |
| Amendment | $95,239 | |
| Original award | $95,239 |
Show all 16
Quick answers
Who received award K43TW011930?
K43TW011930 was awarded to College Of Medicine, University Of Lagos by Fogarty International Center (National Institutes of Health) on July 20, 2022.
How much is award K43TW011930 worth?
$486,246 has been obligated on K43TW011930.
Which agency awarded K43TW011930?
Fogarty International Center (National Institutes of Health) awarded K43TW011930, with funding from National Cancer Institute (National Institutes of Health).
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