Intraosseous antibiotics for osseointegration (IOAOI)

Award Details:

Wake Forest University Health Sciences received a $1,480,812 Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) on September 30, 2025, with completion anticipated by September 29, 2029. The project, titled "Intraosseous Antibiotics for Osseointegration" (IOAOI), is being conducted in Winston-Salem, North Carolina.

Project Scope:

The IOAOI project supports biomedical research addressing military medical challenges through investigation of intraosseous antibiotic delivery methods to improve osseointegration—the biological integration of implants with bone tissue. This research aligns with the DHA's focus on innovative medical solutions for Service Members and addresses orthopaedic injury management relevant to battlefield and military medicine. The award includes specific research terms and conditions requiring quarterly technical reports to ensure progress monitoring and compliance with federal grant requirements. As a leading academic medical center with established expertise in regenerative medicine, biomedical research, and orthopaedic applications, Wake Forest University Health Sciences is positioned to conduct this applied research initiative with direct relevance to military personnel health outcomes.