A hybrid I evaluation of integrative health care for ptsd

The Veterans Medical Research Foundation of San Diego received a $4.8 million Project Grant from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) awarded September 1, 2025, with completion targeted for August 31, 2029. This award funds a hybrid Type I evaluation of integrative health care interventions for Post-Traumatic Stress Disorder (PTSD), combining rigorous clinical trial methodology with implementation science approaches. The research will evaluate the effectiveness and feasibility of integrative health approaches in treating PTSD among veterans, with outcomes designed to inform evidence-based clinical practices and healthcare delivery models.

The project involves a multi-site clinical trial structure with sub-awards to Boston VA Research Institute, Inc., Institute For Medical Research Inc., Biomedical Research Foundation of Central Arkansas, and Oregon Health & Science University. Key deliverables include administration and fidelity assessment of the Clinician-Administered PTSD Scale (CAPS-5) across all trial sites; patient recruitment, screening, enrollment, and data collection at participating VA medical centers in Durham, Little Rock, and Portland; regulatory oversight and budgetary management at each site; and dissemination of trial findings through peer-reviewed publications and presentations. The collaborative research structure leverages expertise across multiple VA healthcare systems to enhance recruitment, clinical implementation, and the translational impact of findings on veterans' mental health outcomes.