Targeting the DPEP1-neutrophil axis in microsatellite stable colorectal cancer

Functional Circulation LLC received a $621,943 Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) for the period of September 30, 2025, through September 29, 2028. The award supports advanced biomedical research investigating the DPEP1-neutrophil axis in microsatellite stable colorectal cancer. The project will be conducted at the company's facility in Lake Mills, Wisconsin, and is designed to advance innovative medical solutions addressing critical healthcare challenges relevant to military service members and the American public.

Under this award, Functional Circulation LLC will deliver hypothesis-driven research and development services, including biomarker discovery, scientific investigation, and translational research activities related to colorectal cancer pathology. This project aligns with the Military Medical Research and Development program's focus on supporting basic, applied, and advanced biomedical research initiatives that transform healthcare through innovation. The three-year performance period provides the company with dedicated resources to investigate potential therapeutic targets and mechanisms that could inform future cancer treatment strategies.