Project Grant HT94252510709

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will provide $545,612 to The Ohio State University to conduct research aimed at reducing adipose tissue dysfunction and metabolic complications after spinal cord injury (SCI). The key objectives are to evaluate the extent to which modulating the A2D1 subunit of voltage-gated...

This $391,250 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to develop effective therapeutic strategies for spinal cord injury (SCI) by evaluating controlled PTEN deletion and chondroitin sulfate proteoglycans (CSPGs) degradation to promote axon regeneration and functional recovery. The key objectives are to: 1) Temporally evaluate...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is supporting research to understand the molecular mechanisms by which sex hormones, such as testosterone and estradiol, modulate wound healing. The $884,888 award, effective September 17, 2024 through March 12, 2025, aims to define how testosterone impairs wound healing through effects on the immune response, and how estradiol may...

This Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) provides $4,182,053.00 to The Spaulding Rehabilitation Hospital Corporation to conduct a clinical trial titled "Breathing Low Oxygen to Enhance Spinal Stimulation Training and Functional Recovery for Aging Adults with Chronic SCI: The BO2ST-II Trial." The award period runs from Sep 30, 2024 to Sep 29, 2028. The project will investigate using low-oxygen...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $455,826 to conduct a double-blind, randomized, placebo-controlled trial to determine the effects of chronic sildenafil administration on vascular remodeling during left ventricular assist device (LVAD) support. The study aims to assess the impact of sildenafil, a phosphodiesterase-5 inhibitor, on aortic stiffness, carotid...

This Project Grant award of $578,275.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports research by The Spaulding Rehabilitation Hospital Corporation in Charlestown, MA to investigate sex and age-related differences in the development of knee osteoarthritis. The research aims to mechanistically interrogate the direct role of soluble microenvironmental factors and extracellular matrix stiffening on the loss of cartilage integrity, using...

This $705,405 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to investigate the role of adventitial fibroblasts, an understudied cell population, in the development and progression of atherosclerosis. The key objectives are to: Determine the mechanism by which targeted genetic ablation of adventitial fibroblasts decreases atherosclerotic plaque formation, despite these cells not directly contributing to the intimal...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $559,893 to the University of Tennessee Health Science Center (UTHSC) to investigate the role of the RSPO2-LGR4 signaling pathway in regulating arterial lymphangiogenesis, vascular smooth muscle cell (VSMC) phenotypic changes, and atherosclerosis development. The project aims to determine the functional impact of VSMC-derived RSPO2 on...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA Program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, provides $506,696.00 to the University of Washington to conduct research on the differential microvascular response to trauma in the spinal cord with sex and age. The research aims to examine and evaluate critical microvascular blood flow parameters that can reduce cervical spinal tissue loss and...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,559,542 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Medical College of Wisconsin, Inc. to study the cardiometabolic impacts of gender-affirming hormone therapy (GAHT) in transmasculine young adults. The project aims to determine the effects of GAHT on vascular endothelial function, cardiometabolic biomarkers, and sex hormone receptor expression in this population, compared to cisgender...