Project Grant HT94252510600

This Project Grant award of $464,315 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research into the role of the L-type calcium channel Cav1.2 in the development of Achilles tendinopathy. The award to the University of Rochester aims to: 1) identify the tendon-specific effects of calcium signaling through Cav1.2 in regulating tendon development, 2)...

This federal Project Grant award of $621,703, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to understand the mechanisms of tendon repair and develop treatments for tendinopathy. The award, with a period of performance from Sep 1, 2024 to Aug 31, 2029, will fund Cornell University's investigation into how changes in glycosaminoglycans (GAGs)...

This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $293,811 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to conduct a 5-year study on the effect of rotator cuff repair (RCR) healing on the progression of degenerative shoulder changes and longer-term clinical outcomes. The key objectives of...

This $360,580 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to develop an engineered extracellular matrix (EECM) that can promote regenerative healing in tendons. The University of Oregon will fabricate anisotropic PEG hydrogel-based EECM scaffolds and evaluate their ability to guide the alignment and matrix deposition of human...

This Project Grant award of $158,912 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) aims to elucidate the role of Wnt signaling in the mechanical maturation of tendons. The research will investigate how Wnt signaling and mechanobiological cues contribute to tendon cell behavior, extracellular matrix organization, and the development of tendon's load-bearing capabilities...

This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $501,450 to The Washington University to conduct research on regulating tendon repair using stem cell-derived extracellular vesicles. The study aims to identify the specific subpopulation and active cargo molecules of extracellular vesicles that can enhance tendon healing and avoid...

This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate the mechanisms underlying adult tendon regeneration in the zebrafish model. The $499,229 award to The General Hospital Corporation (doing business as Massachusetts General Hospital) will fund a 5-year research project to study the role of TGFβ signaling and...

This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $570,878 to the University of Rochester to conduct research on modulating myofibroblast dynamics during tendon healing. The key focus is to define the efficacy of pharmacological activation of the GPR68 receptor in regulating the tenocyte-myofibroblast transition and...

This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to locally deliver a small molecule Hedgehog (HH) signaling agonist to improve tendon-to-bone integration following anterior cruciate ligament (ACL) reconstruction. The $1,060,925 award will fund in vitro release studies to test the duration and bioactivity of the agonist released from...

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $704,514 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the University of Texas Health Science Center at Houston to conduct a multi-center, longitudinal study on acromioclavicular (AC) joint reconstruction techniques. The study aims to compare shoulder mechanics and soft tissue health outcomes for three surgical approaches: 1) coracoclavicular reconstruction alone...