Project Grant HT94252510264

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,304,338 to Wake Forest University Health Sciences to conduct a trans-omics analysis of African American deceased donor kidneys to optimize kidney transplant outcomes. The primary goals are to: 1) Identify APOL1 gene expression profiles in donor kidneys and factors modifying effects...

This $223,176 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the impact of APOL1 copy number variations (CNVs) on kidney disease susceptibility in African Americans. The award recipient, Beth Israel Deaconess Medical Center (BIDMC), will develop computational approaches to characterize the risk variant architecture of APOL1 CNVs and determine the...

This Project Grant award, ID R21HG013814, was provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research Federal Grant Program (CFDA 93.172) to Case Western Reserve University. The $874,886 award, effective from September 9, 2024 to July 31, 2025, aims to quantify and identify environmental modifiers of genetic associations related to kidney outcomes, using the APOL1 genetic model. The proposed research will leverage large, diverse datasets such as the UK...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $297,302 to the University of Miami to investigate the role of the apolipoprotein M (APOM)/sphingosine-1-phosphate (S1P) signaling axis in podocyte injury and glomerular diseases. The key objectives are to: 1) determine if glomerular APOM deficiency correlates with activation of S1P/S1P receptor...

This Project Grant award of $462,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate the effects of Ubiquitin D (UBD) variants on Apolipoprotein L1 (APOL1)-mediated kidney injury. The research will be conducted by Albert Einstein College of Medicine in Bronx, NY and aims to delineate the mechanisms by which a specific UBD...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $133,500 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to Boston Medical Center Corporation (BMC) with a start date of September 1, 2024 and end date of August 31, 2026. The grant will fund research on the relationship between APOL1 genotypes and biomarkers of immune activation and tubular injury in the context of chronic kidney disease (CKD) in sub-Saharan...

This $166,643 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports the development of robust phenotyping pipelines for early detection of collagen type IV-associated nephropathy (COL4A-AN) using electronic health records (EHR) data. The primary goal is to establish scalable phenotyping methods that leverage natural language processing (NLP) and...

This Project Grant award of $829,985.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research supports research to develop new Drosophila, mouse, and human podocyte models to study the interactions between HIV and APOL1-G1 risk alleles that contribute to the development of HIV-associated chronic kidney diseases (HIV-CKD). The research aims to define the mechanisms by which APOL1-G1...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $135,582 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the University of Oklahoma Health Sciences Center to construct a single-cell atlas of mouse and human cells in autosomal dominant polycystic kidney disease (ADPKD). The project aims to understand how molecular and cellular pathways found in ADPKD patients correlate to mouse models, and to identify inter-...

This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $165,364 to The Broad Institute, Inc. to conduct research focused on integrating novel contextual and genomic blood pressure measures to enhance cardiovascular disease prediction and management in young adults aged 18-39 years. The key objectives of this 2-year project are to: 1) identify novel ambulatory blood pressure patterns that capture dynamic responses to...