Project Grant HT94252510207

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $395,009 to the University of California, Davis to lay the foundation for developing a molecular therapy for ADNP syndrome. The key products and services to be delivered under this 2-year award include: Testing the presumed mechanism of action of antisense oligonucleotides (ASOs) that can...

This Project Grant award of $230,250 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research on reversing disrupted developmental sterol biosynthesis caused by prescription medications. The research aims to find a treatment for Smith-Lemli-Opitz Syndrome (SLOS), a rare genetic disorder that disrupts cholesterol biosynthesis, by reducing toxic 7-DHC levels and counteracting...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $698,459 to Epitor Therapeutics, Inc. to develop novel epigenetic editing tools to treat Rett syndrome. The funding will support research to optimize an epigenetic editor comprised of a catalytically dead Cas (dCas) protein fused with a miniature TET demethylase...

This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $147,486 to Emory University to study how defects in the maternal epigenetic reprogramming function of the LSD1/KDM1A enzyme contribute to inherited phenotypes. The research aims to determine how partially compromised maternal LSD1 reprogramming at fertilization leads to...

This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $466,332 to Loyola University of Chicago to develop a novel strategy using locked nucleic acid (LNA) site-blocking antisense oligonucleotides (SBASOs) to increase expression of the MECP2 gene and potentially reverse symptoms of Rett syndrome. The key goals are to...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $160,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Children's Hospital Medical Center in Cincinnati, Ohio. The grant supports research to investigate the epigenetic mechanisms underlying neurodevelopmental defects in Menke-Hennekam Syndrome, a rare genetic disorder caused by mutations in the EP300 gene. The project aims to (1) identify maturation and...

This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $272,395 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the biochemical mechanisms of the G9A/GLP histone methyltransferases and their role in the development of addictive behaviors. The key objectives of this 2-year award, which runs from April 2025 to March 2027, are to: 1) identify specific...

This Project Grant awarded by the National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $294,408 to Emory University from November 1, 2024 to May 1, 2027. The grant will fund research to investigate how coding and non-coding mutations in the ARID1B gene impact gene regulatory networks during neuronal development, leading to neurodevelopmental disorders. The project aims to...

This federal Project Grant award, provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 Child Health and Human Development Extramural Research, will support research into de novo mutations in replication-independent histone genes and their role in rare pediatric neurodevelopmental disorders. The $341,442 award, effective August 23, 2024 through March 31, 2027, will enable investigators at the University of Pennsylvania...

This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $429,000 to the Regents of the University of Michigan to conduct research on the molecular regulators of the GABAergic system in human neurons derived from control and trisomy 21 (Down syndrome) human embryonic stem cells. The primary goal is to discover the underlying mechanisms that cause...