Integrating a natural history registry and biobank for constitutional mismatch repair deficiency (cmmrd): advancing knowledge and therapeutic strategies

This federal Project Grant award for $1,236,001.00 was provided by the Department of the Army Medical Command under the Military Medical Research and Development program (CFDA 12.420). The award will support The Hospital for Sick Children (Sick Kids Hospital) in Ottawa, Canada to integrate a natural history registry and biobank for constitutional mismatch repair deficiency (CMMRD), with the goal of advancing knowledge and therapeutic strategies for this rare genetic disorder. As a leading pediatric research institution, Sick Kids Hospital has extensive experience conducting large multi-site studies and serving as a prime recipient and subcontractor on numerous federal awards, contributing scientific expertise, research infrastructure, and clinical capabilities. This grant will enable Sick Kids to leverage its expertise and resources to establish the integrated registry and biobank, which will facilitate critical research to improve understanding and treatment of CMMRD.