Identification and characterization of the guanine nucleotide exchange factor (GEF) for the small gtpase rheb as a novel target for treatment of TSC…

This Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) provides $148,942 to the Westfaelische Wilhelms-Universitaet Muenster in Germany to conduct research on identifying and characterizing the guanine nucleotide exchange factor (GEF) for the small GTPase Rheb as a novel target for treating tuberous sclerosis complex (TSC). The two-year award, running from July 1, 2024 to June 30, 2026, will support the university's interdisciplinary research, teaching, and support for young researchers in advancing scientific understanding and potential treatment options for this rare genetic disorder. As part of this project, the university has also received five federal grant subawards from various U.S. universities to provide specialized medical imaging, data analysis, biomarker assessment, and scientific research services in support of their broader medical and scientific research initiatives.