SH3BP2-mediated immune activation plays a key role in immunopathogenesis of nephrotic syndrome

The U.S. Defense Health Agency awarded a $1,209,369 Project Grant to the Midwest Veterans Biomedical Research Foundation under the Military Medical Research and Development program (CFDA 12.420). The grant supports research to investigate the role of the SH3BP2 protein in the immunopathogenesis of nephrotic syndrome. The project will be conducted over a 4-year period from September 1, 2024 to August 31, 2028.

The Midwest Veterans Biomedical Research Foundation, a non-profit organization, will lead the research effort. The foundation has previously received federal subawards to study treatments for kidney disease, assess kidney tissue permeability, and analyze disease pathways using mouse models. They have also obtained subawards to develop clinical decision tools for COVID-19 patients and support cancer research through the SWOG NCORP Research Base. Additionally, the foundation has conducted aging research under a subaward to direct activities at the Topeka VA Medical Center.