Project Grant HT94252310077

This $2,147,016 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports the development of a blood-based biomarker test for characterizing disease progression and treatment response in amyotrophic lateral sclerosis (ALS). The awardee, Neurodex Inc., aims to fully validate an analytical method for detecting levels of neuron-derived...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a novel blood-based diagnostic test for early diagnosis and classification of frontotemporal lobar degeneration (FTD). The $638,854 award to Virtici LLC, a for-profit biomedical research company in Seattle, will fund the development of a low-volume, antibody-based assay to...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research to identify mechanisms of neurofilament regulation and turnover in amyotrophic lateral sclerosis (ALS). The $558,182 award to The Washington University in St. Louis will support the development of proteomic assays to analyze neurofilament isoforms and...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $427,625.00 to The Washington University in St. Louis to develop a novel in vitro model for studying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research project will employ direct neuronal conversion to generate induced motor neurons and cortical...

This $227,205 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports a research project to identify the pathological substrate and clinical significance of the "motor band sign" as a marker of upper motor neuron degeneration in amyotrophic lateral sclerosis (ALS) patients. The project will use advanced MRI techniques and...

The federal Project Grant award R21NS139100, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding research to investigate the link between traumatic brain injury (TBI) and neurodegeneration. The $251,250 award will support a study using a knock-in mouse model of mutant TDP-43 to characterize the impact of TBI on neurological deficits and innate...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to characterize novel mixed etiology dementia models compromised for TDP-43 function. The $210,310 award, spanning from June 2024 to October 2026, will enable The Johns Hopkins University to develop mouse models exhibiting Alzheimer's disease, frontotemporal...

The Johns Hopkins University was awarded a $2,399,582 Project Grant from the National Institute on Aging (CFDA 93.866 Aging Research) to study extracellular vesicles derived from the brain as potential biomarkers for Alzheimer's disease. The 3-year grant, which begins on September 1, 2023, aims to identify specific cell surface markers and molecular signatures on brain-derived extracellular vesicles that could be used for early disease detection, monitoring, and understanding Alzheimer's...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to identify novel small molecules that can stabilize functional, multimeric forms of the TDP43 protein. TDP43 is a key target for drug discovery in frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and other TDP43-related neurodegenerative diseases. The $404,058 award to the Regents of the University of Minnesota will fund a high-throughput screening pipeline to...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting the development and optimization of a new animal model for Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). The $374,349 award to the University of North Carolina at Chapel Hill aims to demonstrate the progressive ALS/FTD-like phenotype in aged cohorts of...