Project Grant HDTRA11910031

This $583,047 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how Rift Valley Fever Virus (RVFV) disseminates from the site of infection in the skin to the central nervous system (CNS). The project aims to establish the routes and mechanisms by which RVFV invades the CNS following peripheral exposure, using novel rodent CNS infection models...

This Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program provides $1,062,921 to the University of Washington to advance research on the transmission of the zoonotic disease brucellosis in Bedouin communities in southern Israel. The key objectives are to: 1) measure human-animal contact networks in these communities, 2) model synthetic human-animal networks and develop new methods for generating Brucella genomes, and 3) fit and validate an...

This $625,276 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) is focused on understanding the mechanisms used by the bacterial pathogen Coxiella burnetii to manipulate host cells and cause the human disease Q-fever. The project leverages newly developed genetic tools to investigate how specific Coxiella effector proteins interfere with host immune responses, promote the formation...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $397,135 to Colorado State University to evaluate the potential for zoonotic transmission and human infection by select simian immunodeficiency viruses (SIVs) using a humanized mouse model. The study aims to investigate the cell tropism, CD4 T cell depletion, and sexual transmission capacity of human-adapted SIV...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $636,101 to the University of Texas Medical Branch at Galveston (UTMB) to investigate the mechanisms of RNA packaging in Rift Valley Fever Virus (RVFV), a mosquito-borne pathogen that poses a serious public health threat. The research aims to elucidate how the segmented viral genome is packaged and co-packaged into...

This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to comprehensively investigate the extent and impact of transmitted and acquired HIV drug resistance in Kenya as the country transitions to widespread use of dolutegravir-based antiretroviral therapy. The $645,900 award, with a project period from September 2024 to July 2029, will fund a prospective study to...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, provides $128,052 to Virginia Polytechnic Institute & State University (Virginia Tech) to investigate the role of the Rift Valley Fever Virus (RVFV) NSS protein in modulating the host autophagy pathway. The research aims to define the molecular mechanism of the NSS-LC3 interaction and its impact on RVFV pathogenesis in a...

This Project Grant award from the Fogarty International Center (CFDA 93.989 - International Research and Research Training) provides $1,000,000.00 to the University of Illinois to study pathogen transmission dynamics between wildlife and human settlements in rural western Uganda. The key objectives are to: 1) conduct longitudinal surveillance of adenovirus in wild non-human primates, domestic animals, insects, and environmental samples; 2) apply advanced phylogenetic and bioinformatics methods...

This Project Grant award from the National Science Foundation's Division of Mathematical Sciences, CFDA program 47.049 (Mathematical and Physical Sciences), supports research investigating how the transition from subsistence farming to cash crops impacts infectious disease transmission patterns in rural communities. The $500,000 award to Duke University's Office of Research Administration Division runs from July 1, 2023 through June 30, 2028. The key products and services delivered under this...

This Project Grant award from the Fogarty International Center (CFDA 93.989 - International Research and Research Training) provides $186,254 to the Ifakara Health Institute, a non-profit research organization in Tanzania, to carry out an implementation trial investigating synchronized dog vaccination campaigns as a more effective and efficient approach to preventing rabies transmission from dogs to humans in Africa. The key objectives are to: 1) evaluate if synchronized mass dog vaccination...