Project Grant HC060498007

This $437,461 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports the development of a novel stabilization catheter for His pacing lead implantation. The key product being developed is a sheath with a deployable suction flute that can improve the accuracy and ease of His lead placement for cardiac resynchronization therapy (CRT) in heart failure patients. The goal is to refine the sheath...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $308,526 to Lucie Medical Inc. to develop a novel device for uterine hemostasis (bleeding control) following Cesarean section procedures. The project aims to finalize the device design, validate materials, and conduct functional performance testing, with the goal of progressing to an early feasibility trial. Cesarean sections are the most...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program, aims to develop hyperpolarized gas MRI (HGMRI) signatures to detect and manage acute cellular rejection in lung transplant recipients. The $742,810 award, effective September 1, 2024, supports research by the Rector & Visitors of the University of Virginia to: Correlate HGMRI signatures with tissue pathology, determine HGMRI...

This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $204,295 to the University of Alabama at Birmingham to integrate advanced molecular imaging techniques to quantify HER2 expression and vascular perfusion in HER2-positive breast-to-brain metastases. The overarching goal is to use PET/MRI to characterize intratumoral heterogeneity and delivery of targeted therapies in HER2+ breast cancer brain lesions, in order to provide...

This $390,000 federal Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) will support research at Thomas Jefferson University's Sidney Kimmel Medical College. The project aims to evaluate the use of contrast-enhanced ultrasound (CEUS) and subharmonic-aided pressure estimation (SHAPE) techniques to assess uterine fibroids before and after uterine artery embolization (UAE) treatment. The...

This $299,995 Project Grant awarded by the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) supports research to develop innovative, non-invasive biomarkers from standard-of-care CT imaging that can predict survival outcomes for patients with high-grade serous ovarian carcinoma (HGSOC). The project aims to build a multi-institutional cohort of racially and ethnically diverse HGSOC patients, then use validated radiomics pipelines to...

This Project Grant award for $598,983.00 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports the development of a self-fitting vaginal stent to prevent post-radiation stenosis. The research team at the University of Texas at Austin will design a shape-memory polymer foam stent that can expand to fit the individual patient and maintain vaginal caliber after radiation treatments....

This $718,000 Project Grant awarded by the Department of Health and Human Services' Healthcare Systems Bureau (CFDA 93.493 - Congressional Directives) will enable Loudoun Community Health Center, operating as Healthworks For Northern Virginia, to expand its radiology services by purchasing new ultrasound and mammography equipment. This investment aims to address a substantial backlog of patients requiring these critical diagnostic services, many of whom face barriers to accessing care due to...

This federal Project Grant award of $795,826, provided by the Department of Health and Human Services Agency for Healthcare Research and Quality (AHRQ) under the Research on Healthcare Costs, Quality and Outcomes program (CFDA 93.226), supports a comprehensive 5-year research project at Brigham & Women's Hospital, a subsidiary of Partners Healthcare System. The primary objectives of this research project are to: 1) Identify sociodemographic disparities in radiologist recommendations for...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $306,530.00 to Spinhance LLC to develop a novel cardiopulmonary imaging device to administer the gaseous magnetic resonance imaging (MRI) contrast agent hyperpolarized xenon-129 (HPX). The project aims to design and build an automatic, MRI-compatible system of syringe pumps that can respond to patient breathing dynamics, delivering...