Project Grant F32DA066191
- The National Institute on Drug Abuse awarded Vanderbilt University $236,664 on September 25, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate how cocaine self-administration differentially alters neural encoding of drug and non-drug reinforcers in the nucleus accumbens. The research uses cellular-resolution imaging with microendoscopes to record single-cell neural activity in awake and behaving animals in response to both cocaine and sucrose, tracking how...
- The National Institute on Drug Abuse awarded Icahn School of Medicine at Mount Sinai $181,092 on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate dopamine receptor type 2 (D2)-expressing cells in the ventral hippocampus and their role in cocaine relapse vulnerability. The research comprises three aims conducted in New York, NY through April 30, 2028. Aim 1 characterizes ventral hippocampus D2 neuron activity during cocaine intravenous...
- The National Institute on Drug Abuse awarded the University of Maryland, Baltimore $656,916 on August 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate insular-amygdala conflict processing mechanisms in opioid use disorder relapse prevention. The project, titled "Insular-Amygdala Conflict Processing After Voluntary Abstinence," examines how the anterior insular cortex (AIC) processes conflicting motivations in individuals with opioid use disorder...
- The National Institute on Drug Abuse awarded the University of Pittsburgh $351,314 on August 15, 2026, for imaging brain energy use in cocaine use disorder under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds positron emission tomography studies using [18F]BCPP-EF to measure mitochondrial complex I binding in the brains of treatment-seeking cocaine use disorder subjects compared to healthy controls. Phase 1 research will enroll 18 cocaine use disorder subjects and...
- The National Institute on Drug Abuse awarded the University of Maryland, Baltimore $1,371,874 under the Drug Use and Addiction Research Programs (CFDA 93.279) on March 15, 2026, to investigate the impact of opioid use disorder on mitochondrial dysfunction among antiretroviral therapy-receiving aging people with HIV. The research addresses a gap in understanding how long-term antiretroviral therapy and opioid use disorder compound inflammaging—a low-grade chronic proinflammatory immune...
- The National Institute on Drug Abuse awarded the University of Maryland, College Park $152,300 on August 20, 2026, through the Drug Use and Addiction Research Programs (CFDA 93.279), a federal grant program supporting basic, clinical, translational, and implementation research in substance use, addiction, and related health outcomes. The recipient will conduct a project grant examining neural and cognitive mechanisms underlying perseverance and their disruption following juvenile social play...
- The National Institute on Drug Abuse awarded Duke University $1,744,200 on September 30, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research dissecting and modulating cell type and circuit-specific epigenetic mechanisms of cocaine addiction. The research investigates how cell type-specific molecular changes resulting from repeated cocaine exposure lead to rewiring of brain circuits relevant to cocaine-seeking behavior. Duke will utilize mice repeatedly...
- The National Institute on Drug Abuse awarded the University of Maryland, College Park $107,090 on February 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research mapping how trajectories of perinatal substance use and depression impact neonatal brain development. The research characterizes the longitudinal interplay between perinatal substance use and perinatal depression and examines their combined impact on infant hippocampal volume and growth. The study...
- The National Institute on Drug Abuse awarded Icahn School of Medicine at Mount Sinai $720,691 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to design and develop blood-brain barrier-crossing conjugates that enable delivery of antisense oligonucleotides to the brain for treating cocaine use disorder. The project addresses the lack of FDA-approved medications for cocaine use disorder by leveraging recent advances in antisense oligonucleotide technologies to...
- The National Institute on Drug Abuse awarded Boston Children's Hospital $800,131 on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the functions and mechanisms of a molecularly defined prefrontal cortex neuron subtype in drug addiction. The research focuses on identifying and characterizing POU3F1-expressing layer 5 neurons in the prefrontal cortex and their role in regulating cocaine-seeking behavior. The work employs single-cell RNA sequencing...
The National Institute on Drug Abuse awarded the University of Maryland, Baltimore $153,560 under the Drug Use and Addiction Research Programs (CFDA 93.279) on November 30, 2026, as a Project Grant (F32DA066191). The award funds research investigating how mitochondrial regulation influences structural plasticity and cocaine-seeking behavior in ventral hippocampus-nucleus accumbens projection neurons following prolonged abstinence from intravenous cocaine self-administration. The research addresses relapse vulnerability in cocaine use disorder by examining mitochondrial dynamics—the balance of fission and fusion processes—in upstream brain regions projecting to the nucleus accumbens and their contribution to long-lasting neuronal adaptations and drug-seeking behavior after extended periods of abstinence. Performance occurs in Baltimore, Maryland, with a period of performance through May 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $76.8k | 6/1/26 | ||
| Not listed | $76.8k | 6/1/26 | ||
| Not listed | $0 | 6/1/26 |