Project Grant F32AA032728
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $143,784 Project Grant (CFDA 93.273 - Alcohol Research Programs) to Louisiana State University Health Sciences Center New Orleans on July 30, 2024. The grant will support research to investigate the effects of adolescent opioid exposure on alcohol-induced hyperalgesia (increased pain sensitivity) in adult mice. The research aims to test the hypothesis that exposure to opioids during adolescence increases the magnitude of...
- The National Institute on Alcohol Abuse and Alcoholism awarded Louisiana State University Health Sciences Center-Shreveport $321,929 under the Alcohol Research Programs (CFDA 93.273) on May 1, 2026. The recipient will conduct research into nitric oxide regulation and its role in alcohol tolerance development. The work employs operant conditioning and behavioral testing in mouse models, including medial prefrontal cortex-specific neurogranin knockout and overexpression variants, to investigate...
- The National Institute on Alcohol Abuse and Alcoholism, under the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Minnesota $400,585 on July 16, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the spinal mechanisms of alcohol-induced tactile hypersensitivity. The research addresses the relationship between chronic alcohol consumption and heightened pain sensitivity in individuals with alcohol use disorder. The...
- The National Institute on Alcohol Abuse and Alcoholism awarded Louisiana State University Health Sciences Center New Orleans $567,832 on June 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct research on reducing alcohol drinking through a nonmuscle myosin II small-molecule inhibitor targeting alcohol use disorder. The research focuses on disrupting alcohol-seeking and drinking behaviors in alcohol-dependent animal models using a first-in-class nonmuscle myosin II inhibitor...
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $578,234 on August 20, 2026, under the Alcohol Research Programs (CFDA 93.273) to establish a translational human laboratory model investigating alcohol's effects on pain in persons with co-occurring alcohol use disorder and chronic pain. The research uses a computer-controlled intravenous alcohol clamp to quantify alcohol's biphasic effects on pain perception—analgesia during the ascending phase and hyperalgesia...
- The National Institute on Alcohol Abuse and Alcoholism awarded Louisiana State University Health Sciences Center New Orleans $215,625 under the Alcohol Research Programs (CFDA 93.273) on August 11, 2026. The award funds research exploring mitochondrial defense mechanisms against ethanol-induced dicarbonyl stress in the heart. The project investigates how the mitochondrial protein ES1 (glutamine amidotransferase domain-like 3A) protects cardiac tissue from chronic alcohol-related injury by...
- The National Institute on Alcohol Abuse and Alcoholism awarded the Regents of the University of Colorado, doing business as University of Colorado-Denver, $1,162,583 on September 10, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct research combining laboratory-based pain induction and ecological momentary assessment (EMA) methods to examine age-related differences in the relationship between alcohol use, pain, and inflammation. The research tests two hypotheses: that pain...
- The National Institute on Alcohol Abuse and Alcoholism awarded Louisiana State University Health Sciences Center New Orleans $1,887,924 on September 25, 2025, under the Alcohol Research Programs (CFDA 93.273) to develop and validate geroprotective precision medicine strategies targeting premature aging in people with HIV who use alcohol. The research identifies and tests personalized interventions addressing microbiota characteristics and senescent CD8+ T cells linked to clinical frailty in this...
- The National Institute on Alcohol Abuse and Alcoholism awarded Boston Children's Hospital $489,479 under Project Grant R21AA033213 on August 1, 2026, to characterize physical and emotional pain during protracted withdrawal from alcohol use disorder and identify predictive factors and brain-behavior mechanisms underlying these pain syndromes. The research addresses a gap in understanding how physical pain (musculoskeletal, phantom pain) and emotional pain (hyperkatifeia, stress, anhedonia, social...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Administrators Of Tulane Educational Fund (doing business as Tulane University) $401,626 on September 26, 2025, under the Alcohol Research Programs (CFDA 93.273) to investigate plasma membrane rupture in alcohol-associated hepatitis. The recipient will determine the role of plasma membrane rupture (PMR) in alcohol-associated liver disease and investigate the mechanism by which cholestasis promotes hepatocellular PMR in that...
The National Institute on Alcohol Abuse and Alcoholism awarded Louisiana State University Health Sciences Center New Orleans $158,600 on November 3, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct research identifying the mechanisms underlying alcohol-induced hyperalgesia in adult rats. The project period runs through August 31, 2028, with work performed in New Orleans, Louisiana. The award funds experimental research examining how chronic adolescent alcohol exposure produces lasting pain sensitivity in adulthood and the role of amygdala circuits in mediating this effect. The research tests the hypothesis that chronic adolescent alcohol exposure produces persistent hyperalgesia in male and female rats and identifies the underlying neuroplastic mechanisms, focusing on glutamatergic transmission onto midbrain-projecting central amygdala cells and their relationship to adult pain sensitivity.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 7/13/26 | ||
| Not listed | $79.3k | 5/7/26 | ||
| Not listed | $79.3k | 5/7/26 |