Pinopode formation in endometrial receptivity and fertility
Active Project Grant Awarded Last action
- Award ID
- F31HD122384
- Recipient
-
University Of North Carolina At Chapel Hill UEI D3LHU66KBLD5 Part of University Of North Carolina System Office
- Awarding agency
-
National Institute of Child Health and Human Development
National Institutes of Health, Department of Health and Human Services
- Obligated
- $88,680
Award facts
- Assistance listing
- 93.865 Child Health and Human Development Extramural Research
- Completion date 0% complete
- Originally
- Place of performance
- Chapel Hill, NC 27599, USA
Award details come from USAspending.gov.
Description
- Abstract
- Human fertility is remarkably inefficient, with a large proportion of conceptions ending in early pregnancy loss. A major contributor to this inefficiency, impacting both natural and assisted pregnancies, is failure of blastocyst implantation. Successful implantation requires a receptive endometrial environment during a narrow "window of implantation," yet the molecular and cellular mechanisms governing endometrial receptivity remain poorly understood. This knowledge GAP limits the development of effective therapies to improve pregnancy outcomes. The caron lab investigates pinopodes - large, spherical protrusions on the endometrial luminal epithelium - as a morphological marker of uterine receptivity. Pinopode presence correlates with the implantation window in both mice and humans and is repeatedly implicated with improved outcomes following utilization of assisted reproduction tehnologies such as in vitro fertilization. Adrenomedullin (am) is a key endocrine factor at the maternal-fetal interface enhancing implantation success, embryo spacing and live birth rates in mice. Am has also been shown to promote pinopode number, size and endometrial luminal epitehlial coverage. However, the downstream cellular mechanisms by which am promotes pinopode development remain unknown. We employed gentically-tagged animal systems to isolate and identify epitheilum specific rnas that change with am stimulation. Based on this data, we have developed a series of novel hypotheses that explore how downstream cellular effectors of am signlaing can transform the uterine epithelial surface for enhanced pinopode numbers, and ultimatley improve blastocyst attachment. This proposal harnesses the power of uterine organoids and genetic in vivo models to pave the way towards therapeutic approaches to improve blastocyst implantaion and reproductive outcomes. In parallel, this project will provide rigorous training in reproductive biology, molecular techniques, and data analysis, as well as other tangible skills needed to support development as an independent and innovative scientist aligned with the NIH mission.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $44,340 | |
| Amendment | $0 | |
| Amendment | $44,340 | |
| Original award | $0 |
Quick answers
Who received award F31HD122384?
F31HD122384 was awarded to University Of North Carolina At Chapel Hill by National Institute of Child Health and Human Development (National Institutes of Health) on December 1, 2026.
How much is award F31HD122384 worth?
$88,680 has been obligated on F31HD122384.
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