Mapping tight junction architecture
Active Project Grant Awarded Last action
- Award ID
- F31GM157915
- Recipient
-
The Johns Hopkins University UEI FTMTDMBR29C7
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $196,460
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 89% complete
- Place of performance
- Baltimore, MD 21205, USA
Award details come from USAspending.gov.
Description
- Abstract
- Endothelia and epithelia throughout the body rely on macromolecular complexes known as tight junctions to modulate tissue barrier selectivity, proliferation, and polarity. Tight junctions are intercellular adhesion complexes that form strands around the apical side of cell-cell junctions. Tight junctions act as barriers that protect organs from pathogens while simultaneously allowing for the selective passage of nutrients, which establishes the chemical microenvironments of all tissue compartments. Thus, tight junction dysregulation is a hallmark of many human diseases. According to prevailing models, tight junctions assemble around oligomeric strands of claudin integral membrane proteins. The properties and stoichiometry of these strands are then augmented by the integral membrane protein occludin and the peripheral membrane protein ZO-1. To date, no direct observation of the interaction of tight junction subunits has been observed to support these models. This is a major GAP in our understanding of how the chemical microenvironments in all tissue systems are established, and a roadblock in therapeutic intervention. In this proposal, using an approach integrating structural biology, cell biology, and physiology, we will uncover the structural determinants of tight junction function through elucidating the mechanisms of claudin oligomerization, claudin barrier function, and how tight junction subunits assemble with claudins to tune tight junction function.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $49,538 | |
| Amendment | $48,974 | |
| Amendment | $0 | |
| Amendment | $48,974 | |
| Amendment | $0 | |
| Original award | $48,974 |
Quick answers
Who received award F31GM157915?
F31GM157915 was awarded to The Johns Hopkins University by National Institute of General Medical Sciences (National Institutes of Health) on June 1, 2025.
How much is award F31GM157915 worth?
$196,460 has been obligated on F31GM157915.
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