In vivo structural-based quantitative modeling of aqueous outflow dynamics in glaucomatous eyes
Active Project Grant Awarded Last action
- Award ID
- F31EY039690
- Recipient
-
City Of Philadelphia Trustee Under The Will Of James Wills UEI Y8LFC4TU2EN8
- Awarding agency
-
National Eye Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $52,570
Award facts
- Assistance listing
- 93.867 Vision Research
- Completion date 3% complete
- Place of performance
- Philadelphia, PA 19107, USA
Award details come from USAspending.gov.
Description
- Abstract
- Glaucoma is the global leading cause of irreversible blindness. IT is an insidious often asymptomatic, neurodegenerative ocular disease that, if left untreated, can result in complete loss of visual perception. This makes early detection of glaucoma a critical focus of research in ophthalmology. Once diagnosed, disease progression can be slowed using a variety of effective treatment strategies, all of which aim to reduce intraocular pressure (IOP). Elevated IOP is the leading risk factor resulting from a defective aqueous humor outflow (AHO) mechanism. Current standard clinical treatment for glaucoma consists of eye drops, selective laser trabulectomy (SLT), and filtration surgeries, all of which aim to facilitate egress of aqueous from the eye's anterior chamber into the blood stream until a lower, target IOP is achieved. These therapies can vary in success and longevity in both lowering IOP and slowing down disease progression. Despite treatment mechanisms targeting AHO cellular and structural components, in vivo AHO morphology is not fully understood, in health or disease. This knowledge GAP is at least in part due to limited visibility of AHO and a lack of quantitative analysis tools. The overall goal of this thesis is to establish a morphological framework for the AHO system in healthy and glaucomatous eyes in live people. The strategy is an integrative approach, combining in vivo anterior segment optical coherence tomography (as-OCT) imaging with advanced image processing, deep learning (DL) and computational modeling based on outflow facility to describe the AHO pathway morphology in healthy and glaucomatous eyes. By characterizing the three-dimensional (3D) architecture of key AHO structures and evaluating its changes under various disease states, this study will establish a comprehensive in vivo model of the AHO system for the first time, paving the way for improved knowledge of glaucoma pathophysiology and potential novel treatment outcome measures for improved glaucoma care. The overarching hypothesis is that detectable structural differences within the AHO pathway can be observed in the AHO structure between healthy and glaucoma using comprehensive in vivo modeling, enabling personalized outcome measures, progression tracking, and additional discrimination between health and disease.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Original award | $52,570 |
Quick answers
Who received award F31EY039690?
F31EY039690 was awarded to City Of Philadelphia Trustee Under The Will Of James Wills by National Eye Institute (National Institutes of Health) on September 21, 2026.
How much is award F31EY039690 worth?
$52,570 has been obligated on F31EY039690.
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