Project Grant F31EY039088
- The National Eye Institute awarded The Schepens Eye Research Institute $545,948 on April 1, 2026, under the Vision Research program (CFDA 93.867) to support Project Grant R01EY037230, "Understanding the Role of Reactive Astrocytes in Glaucoma." The award funds research into how astrocytes—the primary cellular component of the optic nerve head—become reactive in glaucoma and alter their support of retinal ganglion cells. The project investigates metabolic changes in astrocytes exposed...
- The National Eye Institute awarded Baylor College of Medicine $1.6 million on September 30, 2025, under the Vision Research program (CFDA 93.867) to conduct basic research on Hippo and Wnt pathway regulation of mammalian Müller glial cell reprogramming and proliferation as a strategy for retinal regeneration in glaucoma, macular degeneration, diabetic retinopathy, and traumatic retinal injury. The research employs genetic loss- and gain-of-function experiments, fate mapping, and single-cell...
- Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded $417,162 to the University of Houston System for a two-year project (July 1, 2025 – June 30, 2027) investigating the birefringence properties of the lamina cribrosa and posterior eye structures as they relate to glaucoma detection and diagnosis. The project addresses a critical clinical need by developing advanced optical imaging methodologies to detect early structural and stress-related changes...
- The National Eye Institute awarded Baylor College of Medicine $487,986 on September 1, 2026, under the Vision Research program (CFDA 93.867) to dissect retinal glial regulatory mechanisms and refine age-related macular degeneration risk loci through high-throughput functional genomics. The research applies innovative genomics approaches to test the hypothesis that retinal glial function is modulated by AMD risk variants in genes enriched within specific functional networks. The work addresses...
- The National Eye Institute of the Department of Health and Human Services awarded $571,206 to the University of Maryland, Baltimore on May 1, 2026, under the Vision Research program (CFDA 93.867) to develop, refine, and validate sensitive and robust adaptive optics-optical coherence tomography (AO-OCT) biomarkers for glaucoma detection and progression monitoring. The project addresses the need for earlier detection of glaucoma progression and mechanistically relevant biomarkers to support...
- The National Eye Institute awarded The Trustees of Columbia University in the City of New York $532,079 on September 1, 2026, under the Vision Research program (CFDA 93.867) to characterize the role of apelin signaling in Schlemm's canal development and its relationship to early-onset glaucoma. The research employs mouse models to express and trace the apelin receptor during Schlemm's canal development, uses conditional and inducible mouse models to study loss of apelin receptor function...
- The National Eye Institute awarded Baylor College of Medicine $646,167 on April 1, 2026, for investigations of cellular and molecular mechanisms underlying age-related macular degeneration (AMD) under the Vision Research program (CFDA 93.867). The project applies high-throughput functional genomics approaches to test whether non-coding risk variants in AMD exert their effects through gene expression regulation enriched within specific functional networks in disease-relevant tissues. The work...
- The National Eye Institute awarded the University of Alabama at Birmingham $636,862 on April 1, 2026, under the Vision Research program (CFDA 93.867) to develop and validate mechanical, vascular, and morphometric biomarkers of eye-specific susceptibility to glaucoma onset and progression. The recipient will perform longitudinal optical coherence tomography imaging to quantify optic nerve head mechanical deformations and vascular perfusion in vivo in an animal model of unilateral glaucoma...
- Federal Grant Award Summary Vanderbilt University Medical Center received a $481,250 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective June 1, 2025 through May 31, 2027. The award funds research investigating the molecular mechanisms by which mutations in the ADAMTS10 gene contribute to primary open-angle glaucoma (POAG), a leading cause of irreversible blindness. The research employs genetically modified mouse models carrying...
- The National Eye Institute (NEI) awarded $764,881 to the University of Colorado-Denver under the Vision Research program (CFDA 93.867) on September 15, 2025, to support a two-year research project investigating the role of advanced glycation end products (AGEs) in primary open-angle glaucoma (POAG). The project will generate fundamental research findings and preclinical data on how AGEs accumulate in trabecular meshwork (TM) tissues and contribute to elevated intraocular pressure and optic nerve...
The National Eye Institute awarded Baylor College of Medicine $100,228 on March 22, 2027, under the Vision Research program (CFDA 93.867) to validate endothelial mediators in glaucoma neurovascular dysfunction using ligandomics technology. The recipient will independently validate the binding selectivity of glaucoma-associated endothelial ligands to ocular hypertensive versus healthy retinal vessels and verify their functional roles in retinal ganglion cell loss and neurovascular dysfunction in glaucoma models. Work proceeds in two aims: global mapping and independent validation of glaucoma-selective endothelial ligands for retinal and optic nerve head vessels, followed by characterization of the functional role and therapeutic potential of ocular hypertensive-selective endothelial ligands to modulate glaucoma pathogenesis in mice. The project centers on the hypothesis that glaucoma-selective endothelial ligands modulate retinal ganglion cell function through neurovascular coupling, extending beyond current therapies that target intraocular pressure alone. Performance occurs in Houston, Texas, with an ultimate completion date of July 23, 2029. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $50.1k | 7/24/26 | ||
| Not listed | $0 | 7/24/26 |