Project Grant F31CA310043
- Federal Grant Award Summary Duke University's Office of Research Administration received a $1.88M Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) awarded on September 23, 2025, with completion targeted for August 31, 2029. The award funds research integrating genome-wide association study (GWAS) data with single-cell omics technologies to identify cellular effectors of glioblastoma predisposition. This research aims to advance...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $302,524 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) on September 10, 2025, with completion scheduled for April 30, 2028. This F32 fellowship award funds postdoctoral research investigating the role of SMARCAL1 (an annealing helicase that catalyzes replication fork reversal) in glioma cell proliferation and tumor immunogenicity. The...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $626,475 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) on June 15, 2026, with completion expected by May 31, 2031. The grant supports fundamental research investigating the role of integrin alpha-6 in breast cancer metastasis to the leptomeninges—the cerebrospinal fluid-containing membranes surrounding the brain and spinal cord. The research...
- Federal Project Grant Award Summary Duke University's Office of Research Administration was awarded $402,135 by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) on May 1, 2026, for a three-year project extending through April 30, 2029. The award funds development of SCHICAR (Single-Cell Histone-level Chromatin Interaction and Accessibility with RNA), a novel tri-modal single-cell platform designed to simultaneously capture high-resolution three-dimensional...
- Federal Project Grant Award Summary Duke University received a $300,000 Project Grant award dated August 1, 2025, from the National Institute of Biomedical Imaging and Bioengineering under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The project, titled "Interpretable Machine Learning and Discovery in Medical Images," will be conducted in Durham, North Carolina, through July 31, 2029. This award supports the development...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $2.89 million Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded September 23, 2025, with completion targeted for August 31, 2029. The project delivers development and validation of a Virtual Preclinical CT (VPCT) platform designed as a digital twin for preclinical cancer modeling of head and neck squamous cell carcinoma...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $120,403 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective June 1, 2026 through May 31, 2027. The grant supports research development focused on pancreatic ductal adenocarcinoma (PDAC) detection and patient stratification for surgical intervention. The project employs ultrasensitive maximum depth sequencing (MDS) technology to...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $395,846 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) on April 1, 2026, with a completion date of March 31, 2031. The award supports research investigating the therapeutic targeting of SMARCAL1 (annealing helicase) as a synthetic lethal vulnerability in alternative lengthening of telomeres (ALT)-positive cancers, specifically...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $415,257 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective July 3, 2025, with completion targeted for June 30, 2027. This research initiative focuses on developing novel chimeric antigen receptor (CAR) T-cell therapies by harnessing B cells from patients following stem cell transplantation for hematological malignancies...
- Federal Grant Award Summary Duke University received a $109,767 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective July 1, 2026 through June 30, 2038. This K99/R00 award supports the development of novel artificial intelligence (AI) frameworks designed to analyze single-cell and spatial transcriptomic data for colorectal cancer research. During the K99 mentored phase, the project will develop and validate SPACT (Spatial Pathway...
Duke University's Office of Research Administration received a $100,228 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective December 1, 2026, through April 30, 2028. The award funds research and development of a verifiable and robust deformable image registration (DIR) method designed to improve precision tracking of diffuse glioma progression, particularly glioblastoma (GBM). The project addresses a critical clinical gap by developing an artificial intelligence-based approach that incorporates blood vessel segmentation and bifurcation matching to achieve sub-millimeter accuracy in non-linear image registration of longitudinal MRI scans. The deliverables under this award include the development of an advanced DIR methodology that leverages blood vessel bifurcations as stable anatomical markers to establish correspondence between pre-operative and post-recurrence MRI scans in GBM patients. The resulting technology will enable precise identification of tumor recurrence origin sites and support refined treatment margins, potentially allowing for improved therapeutic interventions such as targeted radiation dosing to high-risk regions. This research directly supports the National Cancer Program's objectives by advancing diagnostic and treatment planning capabilities for one of the most aggressive forms of adult brain cancer, with the ultimate goal of improving patient outcomes and clinical precision in glioma management.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 4/9/26 | ||
| Not listed | $50.1k | 4/9/26 | ||
| Not listed | $50.1k | 4/9/26 |