Maternal microbiota and breastmilk bile acids as early determinants of infant metabolic health
Active Project Grant Awarded Last action
- Award ID
- F30HD122467
- Recipient
-
University Of Florida UEI NNFQH1JAPEP3
- Awarding agency
-
National Institute of Child Health and Human Development
National Institutes of Health, Department of Health and Human Services
- Obligated
- $88,606
Award facts
- Assistance listing
- 93.865 Child Health and Human Development Extramural Research
- Completion date 0% complete
- Originally
- Place of performance
- Gainesville, FL 32611, USA
Award details come from USAspending.gov.
Description
- Abstract
- Childhood obesity, which affects 1 in 5 U.S. Children, dramatically increases the risk of type 2 diabetes and cardiovascular disease later in life. Early-life nutrition, particularly during lactation, plays a critical role in shaping long-term metabolic health. Although breastfeeding is generally associated with improved outcomes, recent evidence indicates that a maternal high-FAT diet during lactation can predispose offspring to excess weight gain and metabolic dysfunction. One potential mediator of these effects is bile acids-bioactive metabolites present in breast milk that are shaped by maternal diet and GUT microbiota-whose role in early-life metabolic programming remains poorly understood. We recently developed novel small animal models to manipulate the milk bile acid pool and demonstrated that reducing milk bile acids completely prevented maternal high-FAT diet-induced excess weight gain in offspring. This effect required neonatal expression of the bile acid receptor TGR5, suggesting a direct role for milk bile acids in regulating infant metabolism. In specific aim 1, I will test the hypothesis that transient activation of neonatal TGR5 by milk bile acids durably reprograms metabolism through epigenetic modifications. In specific aim 2, I will determine how maternal environmental factors-including diet and the GUT microbiota-modulate the milk bile acid pool and influence offspring growth, and whether maternal live bacterial therapeutics can restore healthy metabolic programming. Impact: these studies will uncover a previously unrecognized role for maternal bile acid signaling in shaping metabolic health and may inform microbiome- or diet-based strategies to prevent childhood obesity.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $44,303 | |
| Amendment | $0 | |
| Original award | $44,303 |
Quick answers
Who received award F30HD122467?
F30HD122467 was awarded to University Of Florida by National Institute of Child Health and Human Development (National Institutes of Health) on December 1, 2026.
How much is award F30HD122467 worth?
$88,606 has been obligated on F30HD122467.
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