Project Grant DP5OD042638
- Federal Grant Award Summary The Broad Institute of MIT and Harvard received a $315,060 Project Grant from the National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), awarded June 10, 2025, with completion targeted for May 31, 2026. The grant supports the development of a cell-type-specific atlas of transcription factor (TF)-element connectivity across human tissues by integrating single-cell and single-nucleus Assay for...
- Federal Project Grant Award Summary The National Human Genome Research Institute (NHGRI) awarded a Project Grant of $178,416 to Whitehead Institute for Biomedical Research, with an award date of August 19, 2025, and completion date of July 31, 2027. Under this award, the Institute will conduct research exploring transcriptional adaptation (TA)—a cellular compensation mechanism that allows cells to mitigate the effects of loss-of-function mutations by upregulating functionally related genes....
- Federal Grant Award Summary Massachusetts General Hospital received a $1.485M project grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 1, 2025 through August 31, 2028. The grant funds research focused on the discovery and characterization of programmable biological systems derived from bacterial-viral interactions, with particular emphasis on identifying and engineering novel RNA-guided...
- Federal Grant Award Summary The Scripps Research Institute received a $276,000 Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) for the period September 1, 2025 through August 31, 2027. The award supports the expansion of BioThings, a distributed ecosystem of biomedical application programming interfaces (APIs) designed to enhance the sharing and integration of biomedical knowledge across the research...
- Federal Grant Award Summary Cold Spring Harbor Laboratory (CSHL) received a $1.75M Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) for a three-year research initiative running from August 5, 2025 through July 31, 2028. The award funds fundamental research investigating how nuclear speckles—non-DNA substructures occupying 15-30% of nuclear volume—regulate gene expression through two primary mechanisms....
- Federal Project Grant Award Summary The National Institutes of Health (NIH) Office of the Director awarded The Washington University a $1,399,500 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) for a three-year period from September 1, 2025, through August 31, 2028. This award supports research on time-lapse epigenome profiling to advance next-generation cellular reprogramming technologies. The project focuses on developing novel methodologies to capture dynamic...
- Federal Grant Award Summary The Broad Institute of MIT and Harvard received a $118,242 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2027. This award supports the development and validation of a novel induced-proximity platform termed Group-Transfer Chimeras for Inducing Proximity (GRIPs), designed to control cellular signaling and...
- Federal Project Grant Award Summary Dartmouth College's Office of Sponsored Projects received a $2.25 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. The award funds the development of novel computational methods to decode the mechanisms of human diseases by reconstructing cellular proliferation, differentiation, and migration...
- Federal Grant Award Summary Carnegie Mellon University received a $286,326 project grant from the National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective June 10, 2025, with a completion date of May 31, 2026. The award supports the development of integrative machine learning methods for analyzing spatial transcriptomics data generated by NIH Common Fund programs, specifically the Human BioMolecular Atlas Program (HubMAP) and...
- Federal Grant Award Summary The University of Massachusetts Medical School received a $460,625 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through August 31, 2030. This award supports fundamental research to advance understanding of gene regulatory networks (GRNs)—the molecular mechanisms that control cell identity, function, and responses to external stimuli in...
The Whitehead Institute for Biomedical Research received a $487,499 Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), awarded February 5, 2026, with completion targeted for January 31, 2031. The primary products and services delivered through this award involve the development of innovative computational methodologies to systematically decipher functional cell-cell communication networks within tissues. The institute will create advanced analytical approaches to accurately define and categorize active intercellular communication networks, investigate their regulatory impacts on cellular states and tissue organization, and elucidate the functional contributions of cell-cell communication in disease genetics contexts. This research initiative directly addresses a critical gap in understanding tissue biology by integrating multi-dimensional transcriptomic data—leveraging recent advancements in single-cell and spatial transcriptomics—to provide comprehensive insights into intercellular communication mechanisms. The computational tools and analytical frameworks developed through this grant will contribute to fundamental understanding of tissue homeostasis maintenance, disease progression mechanisms, and inform the development of novel therapeutic strategies. The award supports basic science investigation focused on transformative research with significant public health implications, consistent with Trans-NIH Research Support program priorities emphasizing scientific merit and innovation.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $487.5k | 2/5/26 |