Project Grant DP2EB041715
- The National Institute of General Medical Sciences awarded The Broad Institute, Inc. $464,032 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods for mapping intercellular circuits governing complex tissues, specifically mucosal epithelia in the intestine, airway, nose, urogenital tract, and related barrier surfaces. The project addresses two key analytical challenges: uncovering intercellular regulatory signals that...
- The National Institute of General Medical Sciences awarded The Broad Institute, Inc. $1,079,960 on September 10, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to expand MicroTutor, an online platform for training biologists in quantitative bioimaging and bioimage analysis. MicroTutor delivers microscopy and bioimage analysis education through interactive learning technologies, combining short video lessons with interactive demonstrations and frequent mastery...
- The National Institutes of Health Office of the Director awarded the Trustees of Boston University $1,144,500 on September 4, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop nanobody-based probes that enable precise, multiplexed, and genetically-encoded perturbations to protein conformations and states in human cells. The work will generate a novel class of probes to realize large-scale, unbiased protein interaction mapping through pooled screening methodologies,...
- The National Cancer Institute awarded The Broad Institute, Inc. $694,642 on August 1, 2026, under the Cancer Biology Research program (CFDA 93.396) to develop live-cell RNA sequencing with single-cell resolution. The project addresses a fundamental limitation in molecular omics measurement: current approaches require cell destruction through lysis, extraction, or fixation to detect molecular contents at high multiplexity, preventing serial measurement of living cells to monitor dynamic processes...
- The National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health, awarded The Broad Institute, Inc. $436,250 on May 1, 2026, under the NCATS program (CFDA 93.350) to develop and validate the RAPID (Rare Disease Analysis Through Pooled Image-Based Identification of Drugs) platform for drug repurposing in rare disorders. The Broad Institute will develop a massively parallel screening platform that integrates pooled optical variant identification,...
- The National Institute of General Medical Sciences awarded Northeastern University $440,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop IMAGE-SEQ, a platform integrating high-resolution in vivo optical imaging with spatially resolved single-cell transcriptomics. The award funds three major expansions of the technology: integration with single-cell proteomics to capture protein-level signaling events and define how proliferative...
- The National Cancer Institute awarded The Broad Institute, Inc., doing business as Broad Institute of MIT and Harvard, $245,297 on July 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop chimeric molecules that trigger generation of neoantigens from proteins dysregulated in infectious disease and cancer. The molecules will be formed by joining clinical-grade protein binders with reactive groups to generate neoantigens that recruit immune system...
- The National Institute of General Medical Sciences awarded The General Hospital Corporation (Massachusetts General Hospital) $444,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop secreted genetically encoded fluorescent biosensors for in vivo extracellular imaging. The project will create a toolkit of biosensors across four research areas: imaging extracellular matrix structures by conjugating fluorescent proteins to lectins and...
- Federal Grant Award Summary The Broad Institute of MIT and Harvard received a $315,060 Project Grant from the National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), awarded June 10, 2025, with completion targeted for May 31, 2026. The grant supports the development of a cell-type-specific atlas of transcription factor (TF)-element connectivity across human tissues by integrating single-cell and single-nucleus Assay for...
- The National Institutes of Health Office of the Director awarded Dana-Farber Cancer Institute, Inc. $845,500 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to design de novo allosteric proteins that sense and respond to small molecules. The research aims to develop "active" proteins that undergo conformational changes upon ligand binding, enabling programmable control of signaling at the nanoscale. The work combines computational design and...
The National Institutes of Health Office of the Director awarded The Broad Institute, Inc. $831,250 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop novel nanoprobes and advanced imaging techniques that extend single-molecule fluorescence microscopy capabilities in living cells. The project addresses fundamental limitations in visualizing G-protein-coupled receptor (GPCR) signal transduction. Current single-molecule imaging methods photobleach within tens of seconds and support fewer than four simultaneous colors, preventing observation of protein dynamics over extended timescales and in native cellular environments. The Broad Institute will develop nanoprobes and cutting-edge imaging techniques to enable single-molecule visualization with more than 20 colors and essentially infinite imaging duration, allowing continuous real-time monitoring of GPCR activation and signal transduction in living cells. This capability directly supports drug discovery, as GPCRs are the target of approximately 35% of FDA-approved drugs. The award period runs from September 1, 2026, through August 31, 2031. Work is performed in Cambridge, Massachusetts. This is a project grant, a form of assistance funding supporting research in a defined scientific area for a fixed period.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $831.3k | 8/26/26 |