Project Grant DP2DK152025
- The National Institute of General Medical Sciences, part of the National Institutes of Health under the Department of Health and Human Services, awarded the University of California Santa Cruz $584,730 on September 10, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate metabolic signaling mechanisms across hibernating mammals. The research applies comparative and functional genomic approaches to identify genes, transcription factors, and signaling...
- This federal Project Grant award, provided by the National Science Foundation's Polar Programs (CFDA 47.078), supports a research study investigating how climate change is affecting the hibernation physiology and phenology of Arctic ground squirrels. The total funding amount is $329,724, with an award date of August 15, 2024 and an ultimate completion date of July 31, 2029. The key products and services to be delivered through this grant include: Extending a long-term dataset on the phenological...
- The National Institutes of Health National Institute on Deafness and Other Communication Disorders awarded Monell Chemical Senses Center $656,479 on May 1, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to investigate influenza virus-induced neuroinflammation in the olfactory sensory system and the mechanisms underlying long-term anosmia. The research tests the hypothesis that genetic deficiencies in antiviral pathways contribute to severe,...
- The National Institute on Aging awarded $792,536 to Monell Chemical Senses Center on September 20, 2025, under the Aging Research program (CFDA 93.866) to deliver the Monell Scientist Entrepreneurial Program for Healthy Aging (MSEP-HA). The award funds a 3-week introductory training program that recruits six graduate students and postdoctoral researchers annually and provides 105 hours of instruction in smell, the biology of aging, and entrepreneurship. Participants receive stipends for...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $152,300 to The Salk Institute for Biological Studies on August 6, 2026, under the Aging Research program (CFDA 93.866). The award is a Project Grant (F32AG099471). The recipient will conduct research using a murine influenza infection model to characterize age-related changes in disease tolerance mechanisms—the physiological defenses organisms deploy to survive infection without necessarily reducing...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded New York University $421,737 on March 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop data-driven, predictive biophysical models of molecular mechanisms underlying cellular quiescence in microorganisms. The research focuses on quantitative relations between physiological traits and molecular processes in...
- The National Institute of Neurological Disorders and Stroke awarded New York University $466,125 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to characterize amyloid-related imaging abnormalities (ARIA) and cerebral amyloid angiopathy (CAA) in a squirrel monkey model of sporadic CAA. The award funds research integrating multiparametric MRI, biofluid biomarker analysis, and neuropathological examination to...
- The National Institute on Aging awarded The Salk Institute for Biological Studies $1.359 million on February 15, 2026, under the Aging Research program (CFDA 93.866) to characterize activity-dependent changes to neuronal populations in the spinal dorsal horn during aging and determine functional consequences for sensorimotor behaviors. The research selectively perturbs activity in different classes of cutaneous afferent neurons to identify inputs that support cell survival in adult mice,...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of The University of Pennsylvania $243,750 on February 11, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds single-nucleus gene expression and chromatin accessibility profiling to identify and characterize neuronal heterogeneity in the murine hypothalamus during sleep and wake states. The research applies single-nucleus RNA sequencing...
- This Project Grant, awarded by the National Science Foundation's Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074), provides $423,262 in funding to the University of Wyoming for a three-year research initiative (August 1, 2025–July 31, 2028). The project investigates the neural circuits and specific neuronal cell types that govern huddling behavior as a form of behavioral thermoregulation in laboratory mice. The research aims to identify and...
The Department of Health and Human Services National Institutes of Health Office of the Director awarded Monell Chemical Senses Center $770,450 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate the cellular and molecular mechanisms of arctic ground squirrel hibernation and metabolic adaptation for identifying novel chronic disease therapeutics. The project establishes arctic ground squirrels as a model system to study natural metabolic plasticity and resilience mechanisms relevant to human health conditions including diabetes, muscle wasting, and ischemic injury. Arctic ground squirrels exhibit three capabilities with direct therapeutic relevance: they naturally develop profound insulin resistance during pre-hibernation, gaining up to 65 percent of body weight and then completely reversing this without diabetes or cardiovascular disease; they maintain muscle mass and strength through 6–8 months of complete inactivity; and they tolerate extreme cold exposure. This research approach marks a shift from traditional disease research that induces pathological states in laboratory animals toward investigating evolutionary mechanisms that allow animals to survive in extreme environments. Monell Chemical Senses Center, a nonprofit research institute in Philadelphia, Pennsylvania, serves as the recipient. Performance takes place in Philadelphia, PA 19104, with a period of performance from September 1, 2026, through June 30, 2031. This is a project grant, the standard NIH assistance type for investigator-initiated research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $770.5k | 8/31/26 |