The cytokine code and neural circuits for sensing inflammation state
Ended Project Grant Awarded Last action
- Award ID
- DP1MH140021
- Recipient
-
The Washington University UEI L6NFUM28LQM5
- Awarding agency
-
National Institute of Mental Health
National Institutes of Health, Department of Health and Human Services
- Obligated
- $2,177,000
Award facts
- Assistance listing
- 93.310 Trans-NIH Research Support
- Completion date
- Funding agency
- Office of the Director National Institutes of Health, Department of Health and Human Services
- Place of performance
- St. Louis, MO 63110, USA
Award details come from USAspending.gov.
Description
- Abstract
- Psychological symptoms are common when fighting an infection: illness causes both physical and mental fatigue and loss of motivation. Such symptoms are harmless when they are transient during acute illnesses, such as the flu. However, chronic inflammatory disorders, including cachexia and endometriosis, produce similar but intensified behavioral disturbances, manifesting as extreme fatigue and depression. This phenomenon likely reflects an evolutionarily ancient communication channel between the immune and central nervous systems, prompting the brain to promote rest to adaptively cope with short-term insults. Yet, how this phenotypic convergence on motivational deficits arises at the level of brain regions and neural circuits controlling such behaviors remains unclear. This project aims to elucidate the function of immune-sensing neural circuits using the cutting-edge tools of neuroscience. By utilizing whole-brain cellular resolution activity mapping and cell-type-specific manipulation, coupled with a quantitative dissection of circuit dynamics, IT intends to bridge the GAP between sensory neuroscience and systems immunology. This will allow characterizing the cytokine codes to elucidate how neural circuits interpret and subsequently guide appropriate behavioral responses. These investigations will use a range of mouse models, spanning both acute infections and chronic inflammatory conditions, such as endometriosis, cardiac cachexia, and cancer cachexia. This research promises a paradigm shift by uncovering the principles through which neural circuits interpret cytokine codes to deduce immune states and reveal novel neuroimmune mechanisms governing mood and motivation. These insights are poised to unlock new therapeutic targets, enhancing treatment strategies to alleviate motivational symptoms for the over 50 million americans suffering from chronic inflammatory conditions.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $1,088,500 | |
| Original award | $1,088,500 |
Quick answers
Who received award DP1MH140021?
DP1MH140021 was awarded to The Washington University by National Institute of Mental Health (National Institutes of Health) on September 30, 2024.
How much is award DP1MH140021 worth?
$2,177,000 has been obligated on DP1MH140021.
Which agency awarded DP1MH140021?
National Institute of Mental Health (National Institutes of Health) awarded DP1MH140021, with funding from Office of the Director (National Institutes of Health).
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