Project Grant DESC0021606

This Project Grant award from the National Institutes of Health's National Human Genome Research Institute provided $768,678 to Molecular Assemblies, Inc. to develop a fully enzymatic oligonucleotide synthesis cycle using engineered template-independent polymerases and a novel phosphate dNTP blocking group. The award supports the goals of the Human Genome Research program (CFDA 93.172) to accelerate genome research and its application to human health. Specifically, the awardee will engineer...

This three-year, $930,252 Project Grant from the National Science Foundation's Division of Computing and Communication Foundations, under the Computer and Information Science and Engineering program, will support research exploring applications of digital microfluidic technology for DNA storage, computation, and synthetic biology. A team from the University of Minnesota will leverage an electronic platform developed by industrial partner Seagate to manipulate droplets and assemble DNA at...

This $600,000 Project Grant from the National Science Foundation's Computer and Information Science and Engineering program will fund research at the University of Texas at Austin to develop DNA-based storage and computation techniques. Specifically, the award supports the creation of a "SIMD-DNA" paradigm that uses strand displacement reactions to manipulate digital data encoded in the topological structure of DNA. This approach aims to enable parallel, in-memory computation without...

This Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program provides $250,000 to the Massachusetts Institute of Technology (MIT) to establish a sustainable, energy-efficient manufacturing framework that uses DNA to position quantum materials on silicon chips with extraordinary accuracy and versatility. The goal is to develop a sub-10 nanometer manufacturing approach for photonic quantum technologies through two complementary...

This Project Grant award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) provides $274,932 to Femtofluidics Incorporated to develop hardware that can rapidly and inexpensively synthesize DNA-encoded libraries (DELs) for accelerating drug discovery. The goal is to build a device that can perform combinatorial chemistry on nanoliter to picoliter volume droplets using an electronic substrate, without any moving or mechanical parts. This technology...

This $100,000 two-year Project Grant from the National Science Foundation's Office of Emerging Frontiers and Multidisciplinary Activities, under the Engineering (47.041) program, will support research at Boise State University to develop a co-design model integrating DNA nanotechnology and two-dimensional materials for advanced semiconductor manufacturing and workforce development. Specifically, the University will design DNA nanostructure templates for atomic precision patterning and doping...

Triton Systems, Inc. received a $249,712 Project Grant award from the Department of Energy Office of Science on February 22, 2021 to develop a fast, scalable, automated, one-pot process for assembly of DNA oligonucleotides into large gene sequences. The work will be performed in Chelmsford, Massachusetts through February 21, 2022. The award is being made under the Office of Science Financial Assistance Program (CFDA #81.049), which supports basic research to deliver scientific discoveries and...

This Project Grant award from the National Science Foundation (CFDA 47.041 - Engineering) totaling $1,400,000 aims to advance the manufacturing of ultra-high-density, DNA-enabled nanoelectronics systems. The key goals are to: Develop scalable methods for obtaining high-purity carbon nanotubes, self-aligned single-molecule junctions, and hybrid DNA nanostructures. Establish reliable processes for integrating bottom-up and top-down architectures using field-driven directed assembly and...

This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) provides $452,375 to The Trustees of Columbia University in the City of New York to develop a platform for rapid and efficient generation of multi-site sequence variants using template-guided gene synthesis. The project aims to advance this synthesis approach by optimizing predictive algorithms, experimental protocols, and robotic automation to produce kilobase-sized DNA constructs up...

Cache DNA, Inc. was awarded a $255,819 National Science Foundation Technology, Innovation, and Partnerships Project Grant to develop a massively scalable storage solution for nucleic acids using barcoded polymer packets. The goal of the Phase I Small Business Innovation Research project is to establish a low-cost approach to maintaining the integrity of nucleic acids, including animal, bacterial, and viral genomes, at room temperature for decades without requiring energy-intensive freezing or...