Project Grant DESC0013172

The National Institute of General Medical Sciences (NIGMS) awarded Trestle Optics LLC a $305,647 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to develop a novel photothermal microscopy system for non-destructive, high-resolution screening and sorting of microalgae to identify and enrich strains producing high-value polyunsaturated fatty acids. The project aims to engineer and prototype a microfluidic platform integrating photothermal imaging...

The National Science Foundation Division of Chemistry awarded Columbia University a $442,564 Project Grant under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to develop new microscopy techniques for imaging ultrafast chemical transformations between molecules separated by large distances. Principal Investigator Milan Delor and his research group will leverage polaritons, which are part-light part-matter particles, to significantly increase the sensitivity of optical...

This $769,749 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences will support the development of Fluorescence Enhanced Photothermal Infrared Spectroscopy (FE-PTIR) technology by Photothermal Spectroscopy Corp. The FE-PTIR technique aims to provide simultaneous fluorescence microscopy and sub-micron infrared spectroscopy to map the distribution of fluorescently labeled biomolecules within cells and tissues while also analyzing their chemical...

Trestle Optics LLC received a $256,380 Project Grant from the Department of Energy Office of Science under the Office of Science Financial Assistance Program (CFDA 81.049) to fund the Quantifying the Algal Metabolome through Photothermal Microscopy project. The grant aimed to advance understanding of algal metabolomes through the development of photothermal microscopy techniques. Trestle Optics will leverage its expertise in photothermal microscopy to develop new methods for visualizing and...

This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) supports the design, optimization, modeling, and initial validation of a high-sensitivity integrated photonic Raman spectrometer by Perceptra Technologies, Inc. The $275,000 award aims to demonstrate the technical feasibility of compact, low-cost optical sensors that can provide on-demand and real-time chemical analysis, addressing the lack of...

This $500,000 Project Grant from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), supports research at Southern Methodist University to advance quantitative chemiluminescence imaging techniques. Professor Alexander Lippert will develop near-infrared and short-wave infrared ratiometric chemiluminescent probes, kinetics-based probes, and microscopy methods to enable precise quantification of analytes like oxygen, pH,...

The National Institute of General Medical Sciences (NIGMS) awarded a $1,085,690 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Medical College of Wisconsin, Inc. (MCW) to purchase an Abberior 3D-STED super-resolution microscope. This high-end imaging system will be installed at MCW's Advanced Cell Imaging Core and will support the research of 14 well-funded NIH investigators across diverse biomedical fields such as cell biology, neuroscience, and...

This $305,000 National Science Foundation (NSF) SBIR Phase I project grant, awarded on March 1, 2025, aims to develop a compact, multi-color super-resolution imaging system capable of visualizing molecular structures in thick biological tissues with nanoscale precision. The project addresses limitations of existing imaging technologies by incorporating advanced features such as adaptive optics and spinning disk technology to minimize optical aberrations and scattering. The research objectives...

The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $300,000 EAGER (Early-Concept Grants for Exploratory Research) project grant to The Research Foundation for The State University of New York (RF SUNY) to establish near-ultraviolet (NUV) coherent anti-Stokes Raman scattering (CARS) microscopy for highly sensitive imaging of native biomolecules. This technology will be applied to develop label-free digital pathology for brain...

Colorado State University was awarded a three-year, $510,200 Project Grant from the National Science Foundation Division of Chemistry under the Mathematical and Physical Sciences federal grant program (CFDA 47.049). The grant will support development of a tunable, broad bandwidth 2D IR microscope for quantitative chemical imaging near reactive surfaces. This instrument will allow researchers to observe chemical dynamics with high spatial and temporal resolution, advancing understanding of...