Project Grant 2543428
- Federal Project Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded $672,000 to the Colorado School of Mines under the Biological Sciences program (CFDA 47.074) on June 1, 2026, for a project titled "CAREER: Probing Pathway Complexity of Biomolecular Assemblies Through Coarse-Grained Deep Learning Models." The award supports a five-year research initiative (through May 31, 2031) that will develop computational tools combining...
- Federal Grant Award Summary This National Science Foundation (NSF) Engineering program (CFDA 47.041) CAREER award provides $549,292 in funding to The Research Foundation for the State University of New York to support a five-year research project (June 1, 2026–May 31, 2031) focused on advancing computational understanding of metal-organic frameworks (MOFs). The primary deliverables include the development of an integrated computational framework combining graph theory, molecular modeling, and...
- This $100,000 Project Grant awarded by the National Science Foundation's Biological Sciences program (CFDA 47.074) will support the development of deep-learning models, specifically consistency models, to simulate the long-time-scale dynamics of protein structures. The project aims to address the limitations of current molecular dynamics (MD) simulations in capturing crucial long-duration protein dynamics events, such as protein folding and aggregation. By developing these advanced computational...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $710,128 Project Grant under the Biological Sciences (CFDA 47.074) program to The Research Foundation For The State University Of New York (SUNY) to conduct collaborative research on the "Energy Landscapes of Designed Cold Unfolding Proteins." The research aims to enhance understanding of the distinct three-dimensional shapes that proteins can adopt at extreme cold temperatures and high...
- This National Science Foundation (NSF) Project Grant, awarded under the Engineering program (CFDA 47.041), provides $357,033 to North Dakota State University (NDSU) from August 15, 2023 to July 31, 2026 to support research on protein manipulation and engineering using an electronic biochemical approach. The project aims to develop a single-molecule manipulation technique to study the dynamics of protein-protein interactions, which is critical for understanding the causes of diseases related to...
- This $531,227 CAREER award from the National Science Foundation's (NSF) Engineering program to the University of California, Irvine (UC Irvine) aims to develop a new "OptOGel Proteomics" technique for high-resolution analysis of subcellular protein localization and function. The project will focus initial validation on mapping the nuclear lamina, a cellular structure implicated in cancer and aging. The research seeks to overcome limitations of current spatial proteomics tools by...
- This $100,000 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund a collaborative research project to develop deep-learning models, specifically consistency models, to simulate protein dynamics more efficiently and over longer time scales. The goal is to address the limitations of current molecular dynamics (MD) simulations in capturing the long-time-scale dynamics of protein structures, which are essential for understanding processes...
- Research Foundation of the City University of New York (RF CUNY), doing business as RF CUNY - Advanced Science Research Center, received a three-year $173,091 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049). The award supports collaborative research between professors at New York University and CUNY to develop water-responsive, shape-shifting supramolecular protein assemblies. Specifically, the researchers aim to...
- This $500,000 federal Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) supports research at Northwestern University to develop de novo designed proteins as mechano-responsive junctions in protein-polymer networks. The key objectives are to: (i) synthesize and computationally simulate de novo designed proteins and their respective protein-polymer networks, and (ii) develop techniques for mechanical characterization...
- Project Grant Award Summary The University of Chicago received a $487,525 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026 through December 31, 2030. The award supports fundamental research to develop evolution-based understanding and design principles for protein engineering through the integration of artificial intelligence (AI) and experimental biology. The...
This $763,328 CAREER award from the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) supports research on designing dynamic protein structures with enhanced functionality. Awarded to the Research Foundation of The City University of New York (RFCUNY), operating as the Advanced Science Research Center, on June 15, 2026, with completion targeted for May 31, 2031, the project delivers fundamental research outputs including computational tools, novel methodologies, and experimental data that advance protein engineering. The primary deliverables include comparative analyses of conformational dynamics in designed versus natural proteins, artificial intelligence (AI)-based algorithms for designing proteins with diverse motion profiles, and validation studies demonstrating improved functional performance of newly designed proteins. Beyond research outputs, this CAREER award incorporates educational and public engagement components consistent with NSF workforce development priorities. The project will produce educational materials and public engagement activities, including AI-powered protein design competitions for classroom instruction nationwide and science communication events, thereby supporting broader participation in biological research and enhancing scientific literacy. These integrated research and educational activities align with NSF's strategic priorities in artificial intelligence, biotechnology, and advanced manufacturing, with potential applications in disease detection, drug delivery, clean fuel generation, and environmental remediation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $763.3k | 5/15/26 |