Project Grant 2525519
- This Project Grant award, provided by the National Science Foundation's (NSF) Biological Sciences Program (CFDA 47.074), aims to revolutionize the use of poeciliid fishes (guppies, mollies, and swordtails) as model organisms for genome editing research. The $471,066 award to Texas State University, effective September 15, 2025, through August 31, 2029, will develop new biotechnological tools to enable precise DNA editing in these small, colorful aquarium fish. This will unlock their full...
- This National Science Foundation (NSF) Project Grant award under the Biological Sciences (CFDA 47.074) federal grant program provides $240,000 in funding from January 1, 2025 to December 31, 2027 to conduct research on the evolutionary dynamics of recombination landscapes and adaptive trait architectures across varying degrees of gene flow. The key research objectives are to: (1) generate multiple linkage maps to examine recombination rate as an individual-level phenotype, (2) conduct a...
- This Project Grant award of $240,000 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports a postdoctoral research fellowship focused on understanding the evolutionary consequences of genetic rescue. The project will use data from an experiment with Trinidadian guppies to investigate the genomic basis and adaptive potential of populations following genetic rescue interventions. The fellow will also lead a summer field course for undergraduates at...
- The National Science Foundation awarded a $138,000 Project Grant to support research titled "Parallel Genome and Phenome Evolution within and across Fish Species" from December 2021 through November 2023. The grant was awarded under the Biological Sciences program (CFDA 47.074), which aims to promote advancement in the biological sciences and strengthen the Nation's scientific enterprise through increasing knowledge and understanding of major challenges. Through this two-year award,...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award in the amount of $948,390.00 will fund the development of cell type-specific genetic tools for the freshwater sponge Spongilla lacustris. The project aims to (1) optimize transfection conditions for efficient gene delivery and expression in sponge cells, (2) create a modular plasmid toolkit featuring cell type-specific promoters, fluorescent proteins, and subcellular targeting signals, and (3)...
- This federal Project Grant award of $432,357 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research to understand how fishes have adapted to high-pressure environments in the deep ocean. The research aims to: Characterize patterns of genome evolution across 100 species of perciform fishes found at depths ranging from 0-8,000 meters. Measure structural changes in key biomolecules involved in metabolism, cell movement, and stress responses across...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) will support the "Collaborative Research: The Albatross Re-Collection Project for a Century of Genomic Change in the Tropics." The $343,638 award, effective July 1, 2024 through June 30, 2027, will enable researchers at Rutgers, The State University to compare historical and modern fish samples from the Philippines. The key objectives are to: 1) assemble and annotate high-quality...
- This $794,457 federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will support the development of new genetic analysis tools. The goal is to incorporate molecular and cellular biology knowledge, such as gene expression patterns and regulatory networks, directly into statistical models used to map genes, predict traits, and simulate changes in the genotype-to-phenotype relationships. The research will be conducted using simulated...
- This $269,173 federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) is funding collaborative research at Stanford University to investigate the genetic and energetic basis of mitonuclear incompatibilities during speciation in swordtail fish. The research aims to identify specific combinations of mitochondrial and nuclear genes that create reproductive barriers and impact hybrid fitness, including examining how these incompatibilities...
- This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351 - Research Infrastructure Programs) provides $194,375 to the University of Wisconsin-Madison to develop robust genome editing tools for generating floxed alleles and editing amino acid changes in the zebrafish model system. The project aims to establish a synthetic exon-mediated integration approach to reliably introduce loxP sites into target genes, enabling...
This $1,526,917 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) aims to revolutionize the use of poeciliid fish (guppies, mollies, and swordtails) as a model system for genome editing research. The project will develop new biotechnological tools, including immortalized cell lines and CRISPR-based DNA editing protocols, to enable precise genetic modifications in these organisms. In addition, the award will generate high-quality genome assemblies and functional annotation resources to support broader adoption of poeciliid fishes as powerful models for studying human diseases, animal behavior, and development. The project, which runs from September 2025 to August 2029, will also provide hands-on research opportunities for undergraduate students and engage the public through outreach activities, while training other scientists in these new techniques to build a community of researchers equipped to leverage these animal models.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 8/1/25 |