Project Grant 2514358
- This National Science Foundation Project Grant award of $997,716 provides funding from May 15, 2022 through April 30, 2026 to investigate the molecular mechanisms that maintain the integrity of the bacterial cell envelope under stress conditions. The award was made under the Biological Sciences program (CFDA 47.074) to the Research Foundation of the City University of New York at the City College of New York. Specifically, the awardee will examine how bacteria regulate the post-translational...
- This Project Grant award, provided by the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program, is funding collaborative research to investigate the synthesis and role of the lipid ceramide phosphoglycerate (CPG2) in gram-negative bacteria. The $481,722 award will support research to discover how CPG2 is produced and explain the enzymes responsible, with the goal of understanding the various functions of bacterial lipids. This work will contribute to answering...
- This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $240,000 will fund a 3-year postdoctoral fellowship to research the adaptive response of bacteria to bacteriophage infection and high hydrostatic pressure. The fellow will develop novel fluorescence microscopy techniques to quantify bacterial growth, cell size, and morphology under these environmental stressors using model organisms E. coli, P. aeruginosa, and S. piezotolerans. The project...
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences Federal Grant Program (CFDA 47.074) provides $493,916 to the Massachusetts Institute of Technology (MIT) to investigate how proteins and lipids coordinate the formation and function of membrane-associated condensates. The research aims to improve understanding of how the cell surface is organized, which could enable breakthroughs in biotechnology, disease treatment, and fundamental cell biology. The project...
- This $659,728 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) will support the development of the BioMemBHub cyberinfrastructure. BioMemBHub is designed to advance modeling and analysis capabilities for biomembranes, proteins, peptides, and small molecules. The project will create an integrated platform consisting of seven web servers and three large databases to enable exploration of the structural and dynamic aspects of...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award, totaling $1,117,922.00, supports research to determine the mechanisms of bacterial tyrosine kinase activation and regulation. The Research Foundation of the City University of New York will utilize computational and experimental methods, including biochemical assays, NMR spectroscopy, and mass spectrometry, to investigate the activation of bacterial BY-kinases in both Gram-positive and Gram-negative...
- This National Science Foundation project grant of $512,676 will fund research at Duke University from August 2022 to July 2025 under the Biological Sciences program (CFDA 47.074). The research aims to advance understanding of mechanosensitive channels in bacteria through single-molecule force spectroscopy experiments using an atomic force microscope. Investigators will observe the opening of individual mechanosensitive channels in living E. coli and B. subtilis bacteria in response to mechanical...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $461,575 to Earlham College supports research to investigate how a bacterial enzyme, ProXP-X, recognizes and binds to both L- and D-amino acids, which is critical for protecting bacterial cells from the toxicity of D-amino acids. The project aims to characterize the mechanisms by which ProXP-X identifies and binds its targets, and determine if its activity prevents D-amino acid toxicity in living...
- This $325,937 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports collaborative research at Michigan State University (MSU) to interrogate the interconnection of structural and metabolic dynamics of evolutionarily distinct bacterial microcompartments. The project aims to study the impact of geometry and permeability of microcompartments in two distantly related bacteria under varying realistic environments, with the goal of gaining...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $1,004,927 Project Grant to The Johns Hopkins University from July 1, 2021 to June 30, 2025. The grant supports research titled "Probing Phosphorylation Events in Biological Membranes" under the Biological Sciences program (CFDA 47.074). The goal of the Biological Sciences program is to promote progress in the biological sciences and strengthen the nation's scientific enterprise by increasing...
This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program supports a research project at Bryn Mawr College focused on understanding the molecular mechanisms of phospholipid trafficking in bacterial cell membranes. The $368,978 award, with a performance period from August 15, 2025 to July 31, 2028, will engage student-scientists in interdisciplinary research at the interface of biochemistry, biology, and molecular biophysics. The project aims to elucidate the role of bacterial membrane proteins in the biogenesis pathway of phospholipids, which is essential for bacterial growth and proliferation. The research will utilize a variety of experimental techniques, including in vitro reconstitution, biochemical analyses, protein mutagenesis, molecular dynamics simulations, and cryo-electron microscopy. This work seeks to fill a critical gap in understanding the fundamental processes that support bacterial survival, which can inform the development of novel strategies to combat antibiotic-resistant bacterial infections.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $369.0k | 7/29/25 |