Project Grant 2323058

Award Date 9/1/23
Completion Date 8/31/26
Dollars Obligated $1.1M
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Olivette, MO 63132, USA
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This is a $1,094,620 project grant awarded by the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074) to the Donald Danforth Plant Science Center. The research aims to reveal the molecular mechanisms behind cassava's natural resistance to cassava mosaic disease, a devastating viral pathogen impacting this important food crop across Africa and Asia. Key activities include:

  • Characterizing viral replication rates and fidelity of different DNA polymerase delta subunit 1 (POLD1) genetic variants, and their interactions with viral and host factors through transient assays
  • Testing if the POLD1-mediated resistance mechanism is effective in a distinct pathosystem by transforming the resistance allele into the model plant Arabidopsis
  • Exploring if similar POLD1 resistance alleles exist in germplasm collections for other important crops like tomato and cotton

The research also includes training for undergraduate and graduate students, and public engagement activities. Additionally, the Donald Danforth Plant Science Center has subcontracted work on the viral transient assays to the Eberhard-Karls-Universität Tübingen in Germany. The 3-year project began on September 1, 2023.

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