Project Grant 2319785

Award Date 9/15/24
Completion Date 8/31/28
Dollars Obligated $192K
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Gloucester, MA 01930, USA
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This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant award of $688,676 aims to develop new tools and resources to enhance the use of sea urchins as a research model organism. The key products and services being delivered include: Protocols for efficiently culturing sea urchin cells to investigate gene function in vitro. Techniques for rapid, scalable DNA transfection of sea urchin embryos, adult tissues, and cell cultures to enable conditional and reversible...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $181,981 to the University of Washington (UW) to develop innovative tools and resources to enhance the use of sea urchins as research models. The key products and services to be delivered include: Establishing efficient protocols for culturing sea urchin cells to investigate gene function in vitro. Enabling rapid, scalable DNA transfection of sea urchin embryos, adult tissues,...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant award provides $795,209 to Brown University to create the next generation of tools to enhance the utility of sea urchins as research models. The overarching goals of this 4-year project are to: 1) develop simple and efficient protocols for culturing cells from sea urchin embryos to investigate gene function in vitro; 2) enable rapid, scalable DNA transfection of embryos, adult tissues, and cell cultures for...
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This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $192,388 to the Gloucester Marine Genomics Institute (GMGI) will fund the development of innovative tools and resources to enhance the utility of sea urchins as a valuable research model organism. The key products and services to be delivered under this 4-year grant, which runs from September 2024 to August 2028, include:

  1. Establishing simple and efficient protocols for culturing sea urchin cells to investigate gene function in vitro.
  2. Developing rapid, scalable DNA transfection techniques for manipulating gene expression in sea urchin embryos, adult tissues, and cell cultures.
  3. Promoting standardization of sea urchin husbandry through open hardware solutions and cryopreservation methods for germplasm and cell lines.
  4. Creating virtual, interactive educational materials to engage secondary school, undergraduate students, and the broader research community in sea urchin studies.

These new genetic tools and techniques will enable expanded areas of biological research using sea urchins as a model organism, including studies of fertilization, embryonic development, neurobiology, regeneration, and environmental/disease responses. The project outcomes are expected to significantly advance the utility of sea urchins as an impactful research and educational tool in the 21st century.

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