This $303,254 Project Grant from the National Science Foundation's Division of Environmental Biology, under the Biological Sciences program (CFDA 47.074), will fund research exploring the idea that the earliest adaptive evolution occurred through self-amplifying cycles of chemical reactions, rather than nucleic acids. Over a three-year period from August 2022 to July 2025, Michigan State University will conduct theoretical and laboratory studies to analyze how mixtures of chemicals could...
The National Science Foundation Division of Environmental Biology awarded a $1,126,538 project grant to the University of Wisconsin-Madison under the Biological Sciences federal grant program (CFDA 47.074) to support research exploring the origin of life through ecological dynamics and adaptive evolution. Over a three-year period from August 2022 to July 2025, the university will conduct both theoretical and laboratory research to test the hypothesis that the earliest adaptive evolution occurred...
The Foundation For Applied Molecular Evolution, Inc. received a $426,000 Project Grant award from the National Science Foundation Division of Chemistry on August 15, 2021 to support research exploring the diverse evolutionary power of nucleic acid libraries carrying different information content. The three-year award, scheduled for completion on July 31, 2024, will fund work under the Mathematical and Physical Sciences program (CFDA 47.049). This program aims to promote progress in the...
This $299,999 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) will support research exploring the RNA world and RNA-peptide world hypotheses using a novel dynamic combinatorial chemistry system at the University of Houston, a minority-serving institution. The two-year project beginning August 1, 2022 aims to advance understanding of the role of RNA and peptides in the origins of life. Investigators will employ a system using benzonuclease to cleave...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant awarded to Adelphi University for $311,035 provides funding to identify prebiotic peptides or small proteins that may have played a role in the origin of biological energy generation at the start of cellular life. The 3-year project aims to use artificial intelligence and experimental validation to discover prebiotic oxidoreductases composed only of amino acids available under prebiotic conditions, which could...
This Project Grant award for $502,983, funded by the National Science Foundation's Biological Sciences program (CFDA 47.074), supports research at the University of Texas Rio Grande Valley (UTRGV) to investigate the self-assembly and hereditary properties of primitive cellular compartments (protocells) in the absence of genetic information. The key objectives are to: (i) use catalytic minerals to synthesize and polymerize organosulfur species into amphiphilic molecules; (ii) study the...
The University of Chicago will receive $899,998 from the National Science Foundation under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) for a project grant award titled "Nonenzymatic RNA Replication." Professor Jack W. Szostak of Massachusetts General Hospital and Harvard University will lead research studying prebiotic chemistry relevant to the origin of life on Earth, focusing on how primordial RNA molecules could have replicated without enzymes. The...
The Foundation For Applied Molecular Evolution, Inc. was awarded a $1.2 million Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences to support research titled "COLLABORATIVE RESEARCH: SYNTHETIC AND SYSTEMS BIOLOGY APPROACHES TO SEMI-SYNTHETIC CELLS WITH EXPANDED DNA ALPHABETS" from August 15, 2021 through July 31, 2024. The grant supports research under the NSF's Biological Sciences program (CFDA 47.074), which aims to advance fundamental...
This $961,999 federal Project Grant, awarded by the National Science Foundation (NSF) under its Biological Sciences (CFDA 47.074) program, will support research to elucidate the early origins and evolution of Asgard archaea in geothermal environments. The project will collect and analyze microbiome samples from understudied hot springs in the western U.S. to identify new Asgard archaeal lineages, reconstruct their genomes, and study their evolutionary history. This work aims to advance...
This $1,120,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) aims to explore the boundaries of life's genetic alphabet beyond the natural 4-letter system (A, T, G, C). The research will develop model systems to study the biomolecular properties of a 6-letter genetic alphabet (A, T, G, C, P, Z) and map critical interactions necessary for translation of this expanded genetic code. The project will use synthetic biology and chemical...