The National Science Foundation awarded Wabash College a $466,738 Project Grant under the Biological Sciences program (CFDA 47.074) to develop a novel protein control system in the nematode Caenorhabditis elegans. The college will engineer a nematode-optimized degradron-latching orthogonal cage/key protein system called NEMDEGRONLOCKR to enable targeted degradation of regulatory proteins. Researchers will computationally design, biophysically test, and apply CRISPR-CAS9 to fuse NEMDEGRONLOCKR to genes of interest. Undergraduate students will engage in interdisciplinary research applying this new tool. Strains and constructs will be deposited in public repositories, disseminating results. The grant reflects the program's goals of advancing biological knowledge and understanding major problems through basic research support. The award period is February 1, 2022 through January 31, 2025.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $466.7k | 1/19/22 |