Iucrc phase II+: johns hopkins university: advanced mammalian biomanufacturing innovation center (ambic)

Ended Project Grant Awarded Last action

Award ID
2100800
Recipient
Awarding agency
Obligated
$1,061,000

Award facts

Assistance listing
47.074 Biological Sciences
Completion date
Funding agency
Division of Molecular and Cellular Biosciences National Science Foundation
Place of performance
Baltimore, MD 21218, USA

Award details come from USAspending.gov.

Transactions

Action Obligated Date
Amendment $91,000
Amendment $145,000
Amendment $91,000
Amendment $169,000
Amendment $91,000
Amendment $115,000
Amendment $91,000
Amendment $8,000
Original award $260,000

Subawards

Subrecipient Amount Awarded
Clemson University Clemson University, led by Dr. Harcum, will test the clones made by Dr. Blenner (UD) in shake flask fed-batch cultures for each target provide by Dr. Blenner.… $30,000
University Of Maryland, College Park UMD will develop multimodal PATs and generate a Multimodal Dataset, apply the PAT platform to CHO cell cultures, and develop predictive models $65,000
University Of Delaware The University of Delaware (UD) team will develop a computationally efficient, CFD-informed risk-assessment framework for mammalian-cell bioreactor scale-up,… $100,000
University Of Maryland, College Park UMD will first gather the relevant AMBIC record and convert it into text and images for a chatbot knowledge base. Meeting recordings will be transcribed using… $53,000
University Of Delaware Delaware will immortalized Chinese hamster ovary, lung, heart, and liver cell banks with greatly reduced doubling times, and candidate doubling time-reducing… $35,000
University Of Delaware Delaware will explore several previously unexplored targets to i) expand the ER and Golgi, ii) manage the UPR to effectively elicit positive aspects while… $70,000
University Of Massachusetts Lowell Professor Seongkyu Yoon’s group will work closely on the one-year AMBIC project entitled “2026-I-06: Unifying AMBIC Knowledge for Decision-Making.” During the… $41,000
University Of Massachusetts Lowell UMass Lowell will focus on the design, fabrication, and initial testing of H₂O₂ and dissolved oxygen fiber-optic sensors, while Yoon’s group will develop the… $100,000
Regents Of The University Of Michigan In this project, we propose to demonstrate that specific productivity of CHO cells (i.e. protein produced per cell per unit of time) can be increased by… $110,000
University Of Delaware This project will enable near real-time monitoring of CHO cell stress in a dose-responsive manner that will not inhibit normal cellular processes. Spermine… $120,000
University Of Delaware This project will use of a dynamic feedback system to regulate ER stress represents an innovative and highly impactful advance for protein manufacturing.… $140,000
University Of Delaware This project introduces an integrated, model-driven framework to optimize CHO processes with significantly fewer experiments. The approach is novel in its… $200,000
Clemson University Clemson will use fed-batch shake flask cultures of the NISTCHO cell line will be conducted with and without dipeptide supplements. The dipeptides to be examined… $200,000
University Of Delaware This project introduces an RNA barcode for the first time in CHO cells, enabling single-cell lineage tracing with scRNAseq. Biomarker ID is typically done in… $200,000
Clemson University Clemson will enable near real-time monitoring of CHO cell stress in a dose-responsive manner that will not inhibit normal cellular processes. Spermine… $120,000
University Of Massachusetts Lowell This project aims to deliver a next-generation AMBIC media with significantly improved productivity by introducing novel third-party components and refining… $200,000
University Of Massachusetts Lowell The goal of this project is to elucidate the roles of native and oxidized fatty acid metabolites in regulating CHO cell performance, with the specific aim of… $100,000
University Of Maryland, College Park UMD objective is to characterize the temporal expression profiles of key cell surface and intracellular markers in multiple clonal cell lines using flow… $50,000
University Of Maryland, College Park UMD will make use of a new device built at Maryland for characterizing oxidative stress in culture fluids and cells (Hyper, ruGFP) in part to explore hypoxia… $110,000
Clemson University Perfusion bioreactors outperform fed-batch cultures in volumetric productivities due to prolonged cultures and continuous harvesting. Higher perfusion rates… $140,000
University Of Delaware Project objectives: Identify a modest library of potentially high activity transposases that are not encumbered by IP, using literature and BLAST. 2.Determine… $120,000
Regents Of The University Of Michigan In this project, we will perform mechanistic studies that will elucidate how lactate shift is impacted by several process shifts and how we can use process… $110,000
University Of Massachusetts Lowell UMass Lowell will investigate parameters involved in cell culture and transient transfection and characterize their impact on product quality attributes… $164,000
Clemson University Clemson will uild on the predictive ability of previously (AMBIC 2021-26) developed deep-learning models towards real-time control. Collect targeted… $30,000
University Of Massachusetts Lowell UMass Lowell will investigate: (1) Gather requirements for typical data conventions (2) Write Python script to normalize spreadsheet data via wizard. (3)… $30,000
University Of Massachusetts Lowell UML will investigate the production dynamics of NAD/NADH and FAD/FADH by the TCA cycle, alongside ATP generation within the Electron Transport Chain (ETC) using… $30,000
University Of Massachusetts Lowell UMass Lowell will investigate: (1) Gather requirements for typical data conventions (2) Write Python script to normalize spreadsheet data via wizard. (3)… $30,000
University Of Massachusetts Lowell UMass Lowell's goal of this project is to better understand the role fatty acids and oxidized fatty acids metabolites on CHO cell performance and to identify… $30,000
Yale Univ novel data linkage to understand cancer inequities. $64,497
University Of Massachusetts Lowell 2022-13.1 SA: Elucidating concentrated media component bucketing strategies and order of addition for process intensification $48,000
Clemson University Chinese hamster ovary (CHO) cells undergo stress during culture (shear-induced stress) or cloning (production-induced stress) that impacts performance but is… $30,000
University Of Maryland, College Park 1. Identify metabolic biomarkers using DOE 2. Determine sensor that best correlates with high cell density targets 3. Activate switch from growth to… $80,000
Regents Of The University Of Michigan Univ of Mich will be exchanging small molecules, peptides, proteins, RNA, etc., cells that could be homogenizing the cell population and dynamically… $110,000
Clemson University This research group has the instrumental capabilities to perform comprehensive determinations of the total, free, and ligated metals present in native media… $160,000
University Of Massachusetts Lowell This proposal attempts to develop an inducible stable producer cell line for rAAV production using targeted integration in HEK293 cells via the CRISPR/Cas9… $100,000
University Of Massachusetts Lowell UMass Lowell will develop a shareable AMBIC chemically defined media for the community which will enhance knowledge of how individual media components play in… $100,000
University Of Delaware UDel will build robust predictive capacity into the model, model regression of data collected across a wide range of process conditions will be required. To… $140,000
Clemson University Clemson will build robust predictive capacity into the model, model regression of data collected across a wide range of process conditions will be required.… $140,000
University Of Delaware Build upon the prior AMBIC project’s success and continue to be a collaborative and active member of the multi-institutional project team led by UMass… $100,000
University Of Delaware Univ of DE will be exchanging small molecules, peptides, proteins, RNA, etc., cells that could be homogenizing the cell population and dynamically regulating… $110,000
University Of Delaware UDel will attempt to develop an inducible stable producer cell line for rAAV production using targeted integration in HEK293 cells via the CRISPR/Cas9 system.… $100,000
University Of Maryland, College Park The University of Maryland effort will measure the oxidative state of cell culture media, antibody product, and other reagents using mediated electrochemical… $95,834
University Of Massachusetts Lowell UMass will develop a shareable AMBIC chemically defined media for the community which will enhance knowledge of how individual media components play in AAV… $100,000
University Of Maryland, College Park IUCRC Phase II + Johns Hopkins University Advanced Mammalian Biomanufacturing In $30,000
University Of Delaware This project creates a standard tool kit for the AMBIC community to use. It creates a series of high expression sites for gene integration. Finally, the ability… $90,000
University Of Massachusetts Lowell The first phase of the study will evaluate the HCP profile in the cell culture over a range of cell morphology including two AMBIC cell line specific HCP… $133,000
Regents Of The University Of Michigan Univ of Michigan will apply our 13C-tracing and lipidomics methods to elucidate the impact of supplementing CHO cell culture media with a variety of FAs and… $93,000
Clemson University The underlying mechanisms of redox homeostasis on critical product quality attributes (CQAs), specifically charge heterogeneity, are not yet fully understood.… $134,166
Clemson University Clemson aims to utilize deep learning combined with transfer learning to establish a framework for faster media formulation development with fewer experiments… $190,000
Regents Of The University Of Michigan UMich will use the NIH AMBIC CHO cell line and chemically defined cell culture media supplemented with one or more of the citric acid cycle metabolites (0-10… $50,000
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Quick answers

Who received award 2100800?

2100800 was awarded to The Johns Hopkins University by Division of Engineering Education and Centers (National Science Foundation) on August 1, 2021.

How much is award 2100800 worth?

$1,061,000 has been obligated on 2100800.

Which agency awarded 2100800?

Division of Engineering Education and Centers (National Science Foundation) awarded 2100800, with funding from Division of Molecular and Cellular Biosciences (National Science Foundation).

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