Project Grant 20256701845102
- This Project Grant award of $297,000.00 from the U.S. Department of Agriculture's Agriculture and Food Research Initiative (CFDA 10.310) will support research at Tuskegee University to investigate the potential health benefits of blueberry polyphenols in preventing metabolic syndrome-induced diabetes. The project aims to process whole blueberries into freeze-dried powders, analyze their polyphenolic content and anti-oxidant/hypoglycemic properties, and then formulate them into feed diets for a...
- This federal Project Grant award, valued at $649,753.00, was provided by the USDA National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310). The grant supports research at North Carolina State University (NC State) to investigate the relationship between the chlorogenic acid content of blueberries and their ability to lower trimethylamine N-oxide (TMAO) levels and prevent atherosclerosis. The key products and services to...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Massachusetts Medical School is focused on understanding how the gut microbiome influences neurodegeneration and protects against Alzheimer's disease. The $647,979 award, effective September 30, 2024 through August 31, 2025, will leverage the C. elegans model system to: Determine how bacterial production of vitamin B12 protects against neurodegeneration pathways. Examine...
- The University of Nebraska-Lincoln will receive $638,000 from the United States Department of Agriculture National Institute of Food and Agriculture under the Agriculture and Food Research Initiative competitive grants program to study the effects of milk exosomes on spatial learning and memory. Specifically, the researchers will examine how dietary depletion of milk exosomes alters the quantity and quality of outer membrane vesicles and cytoplasmic membrane vesicles secreted by gut bacteria....
- The University of South Florida received a $3,385,215 Project Grant award from the National Institute on Aging, part of the National Institutes of Health within the Department of Health and Human Services. The grant was awarded under the Aging Research program (CFDA 93.866) to fund research titled "Microbial Therapy Improves Gut Permeability to Reduce Cognitive Decline and Alzheimer's Disease." The grant will support research from August 2021 through July 2024 to study the impact of...
- This Project Grant awarded by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), is funding research to investigate the role of oral microbially-induced exosomes in the pathogenesis of Alzheimer's disease (AD) and related dementias (ADRD). The $550,627 award, with a project period from January 1, 2025 to November 30, 2029, is being provided to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to conduct...
- The National Institute on Aging (CFDA 93.866) awarded a $513,740 Project Grant to President and Board of Trustees of Santa Clara College to develop a novel exosome-based nano-scavenger (EBNS) for the targeted removal of amyloid-beta proteins, which are a key characteristic of Alzheimer's disease. The 3-year project aims to genetically engineer exosomes to load both amyloid-targeting antibodies and amyloid-degrading enzymes, leveraging the intrinsic tissue-penetrating abilities of exosomes as a...
- This federal Project Grant award of $856,580 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 5-year research project to investigate the relationship between the gut microbiome and Alzheimer's disease and related dementias (AD/ADRD) in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort. The project aims to elucidate the microbial origins of AD/ADRD in the Latino population, which has double the risk of AD/ADRD compared to non-Latino whites. Key...
- This $3,952,330 Project Grant awarded by the United States Department of Agriculture's National Institute of Food and Agriculture (USDA-NIFA) under the Specialty Crop Research Initiative (CFDA 10.309) aims to increase the competitiveness and sustainability of the U.S. blueberry industry by developing methods to improve fruit quality and reduce crop loss. The research team will address challenges to blueberry fruit quality through objectives such as measuring pathogen diversity, collecting crop...
- The University of South Florida (USF) was awarded a $3,297,926 project grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to develop novel biomaterials that can prevent, halt, and potentially cure Alzheimer's disease (AD). The objective of this 4-year project is to advance USF's preliminary work on designing peptide hybrid biomaterials that can stabilize the helical conformation of the amyloid-beta (Aβ) peptide, thereby shifting the equilibrium of Aβ aggregation away...
This Project Grant award, provided by the U.S. Department of Agriculture's National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310), supports research to evaluate the protective impact and pharmacological activities of blueberry-derived nanocomponent exosomes (BBDEXO) on mitigating symptoms of Alzheimer's disease (AD). The central hypothesis is that BBDEXO can modulate gut microbiota metabolites, inhibit gut inflammation, and alleviate cognitive impairment through the microbiota-gut-brain axis. The $300,000 award to Western New England University will fund a 2-year project with the objectives of: 1) assessing the stability, release, cellular uptake, and efficacy of BBDEXO in targeted microbiota, gut, and brain cells; and 2) investigating the influence of BBDEXO on the microbiota-gut-brain axis in mouse models transplanted with AD patient microbiota. The project aims to deepen the understanding of blueberry's beneficial effects and lay the groundwork for developing targeted nutritional interventions to address Alzheimer's disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $300.0k | 9/2/25 |