Project Grant 20253352245304
- This Project Grant awarded by the United States Department of Agriculture's National Institute of Food and Agriculture under the Biotechnology Risk Assessment Research Grants Program (CFDA 10.219) provides $649,753 to the University of Maryland, College Park to conduct research on the unintended effects of multiplexed genome editing using cytosine base editors (CBEs) in rice. The key objectives are to: 1) develop improved CBEs derived from CRISPR-Cas9 and CRISPR-Cas12a for high-efficiency...
- This $649,998 federal Project Grant award was provided by the U.S. Department of Agriculture's (USDA) National Institute of Food and Agriculture (NIFA) under the Biotechnology Risk Assessment Research Grants Program (CFDA 10.219). The grant was awarded on September 15, 2025 to the University of Connecticut (UConn) to systematically investigate the unintended consequences of multiplex genome editing in tomato plants. The study aims to compare multiplex-edited plants with genetically transformed...
- The Department of Agriculture's National Institute of Food and Agriculture (USDA NIFA) awarded a $650,000 Project Grant under the Biotechnology Risk Assessment Research (BRAG) program (CFDA 10.219) to North Carolina State University. The project aims to genetically engineer tomato plants to produce CRISPR pollen that can destroy seed development in non-genetically engineered tomato plants, thereby limiting pollen-mediated gene flow from genetically engineered to non-genetically engineered...
- This $645,674 Project Grant award from the U.S. Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA) under the Biotechnology Risk Assessment Research (BRAG) program (CFDA 10.219) will support comprehensive evaluation of genome-wide off-target effects and phenotypes in citrus gene-edited lines. The goal is to provide valuable data to assist regulatory agencies in effectively assessing the risks of gene-editing technology for engineering citrus species, a critical...
- The University of Maryland, College Park was awarded a $1,205,836 Project Grant from the National Science Foundation Division of Integrative Organismal Systems under the Biological Sciences federal grant program (CFDA 47.074) for the period of March 1, 2022 through February 28, 2025. The grant funds the development of highly efficient and unconstrained CRISPR systems for plant functional genomics. Specifically, the University will utilize the funding to advance CRISPR technology for analyzing...
- The Regents of the University of Minnesota, through its Office of Sponsored Projects Administration, was awarded a $551,099 Project Grant from the U.S. Department of Agriculture (USDA) National Institute of Food and Agriculture under the Biotechnology Risk Assessment Research (BRAG) program (CFDA 10.219). The grant will fund a 3-year study to investigate the potential for unintended changes due to CRISPR/Cas9 genetic modifications of multiple gene copies or gene family members in soybeans. The...
- The University of Maryland, College Park will receive $499,961 from the US Department of Agriculture National Institute of Food and Agriculture under the Biotechnology Risk Assessment Research program to conduct genomic monitoring of insect pest populations for emerging resistance to pest management technologies from August 1, 2022 to July 31, 2025. The project aims to assess the strengths and limitations of genomic monitoring approaches for detecting emerging resistance in different pest...
- The National Science Foundation awarded a $307,400 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Missouri System to develop epigenetic editing tools for improving crop plants. The project aims to expand the capabilities of genome editing by enabling targeted changes in gene expression, rather than just DNA sequence, to generate novel traits in important crops like rice and tomato. Key objectives include adapting the epigenetic editing approach...
- This $934,421.00 Project Grant award from the U.S. Department of Agriculture's National Institute of Food and Agriculture (NIFA) under the Grants for Agricultural Research, Special Research Grants program (CFDA 10.200) is funding research and development activities at the University of Maryland, College Park. The award supports the university's sophisticated research capabilities across areas such as aquaculture, crop breeding, pest management, genetics, disease control, and sustainable...
- The Department of Agriculture's National Institute of Food and Agriculture awarded a $649,916 Project Grant to Oregon State University under the Biotechnology Risk Assessment Research (BRAG) program (CFDA 10.219). The grant supports research to develop improved tools for excising transgenes used in genetic engineering, particularly for plants like forest trees that are difficult to genetically modify and have high ecological impacts. The research will: 1) create novel recombinase target sites...
The University of Maryland, College Park was awarded a $649,999 Project Grant from the U.S. Department of Agriculture's (USDA) Biotechnology Risk Assessment Research Grants (BRAG) Program (CFDA 10.219). The grant, awarded on September 15, 2025, supports research to test the efficacy and specificity of multiplex mutagenesis in cis-regulatory regions using genome editing to engineer broad and durable disease resistance against two fungal pathogens in tomato, a vegetable crop. The key research objectives are to: 1) evaluate the efficiency of genome editing at inducing multiple targeted mutations in at least four susceptibility genes, 2) characterize trait efficacy and potential pleiotropic effects on agronomic performance, and 3) determine potential off-targets and other complex structural variations that could originate from multiplex genome editing. This research aims to provide an extensive dataset to evaluate the efficacy and specificity of complex genome editing approaches in tomato, with the goal of supporting regulatory decision-making on the environmental effects of genetically engineered organisms.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $650.0k | 9/15/25 |