Project Grant 20216701735782

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $875,714 to the University of Washington to develop and validate a toolbox of AI-designed mini-proteins (epibinders) that can drive more efficient differentiation of pluripotent stem cells into functional pancreatic islet tissue. The goal is to enhance the therapeutic potential of stem...

The National Institutes of Health (NIH) Office of the Director awarded a $975,027 Cooperative Agreement under the Trans-NIH Research Support program (CFDA 93.310) to The George Washington University. The project, titled "Enhancing and Making Biomarker Knowledge FAIR Using Contextual CFDE Data", aims to refine and populate a biomarker data model through a partnership with the NCI-supported Early Detection Research Network (EDRN). The initial focus is on cancer biomarker data, with plans...

This Cooperative Agreement award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $1 in funding to the University of California, San Diego (UCSD) to develop the concept of the "human metabotype." The goal of this project is to leverage data from three major NIH-funded initiatives - MOTRPAC, Nutrition for Precision Health (NPH), and the Human Health Exposure Analysis...

This $800,000 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) to develop new combinatorial pharmacology approaches for regulating multiple neuron types in the brain to effectively promote satiety and reduce body weight in mouse models of obesity. The research aims to...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $854,803 to establish a comprehensive, curated data repository for storing and enabling analysis of indirect calorimetry data related to energy homeostasis and body weight regulation. The award to Beth Israel Deaconess Medical Center, Inc. will create the "CALRepository", a centralized database for...

This $499,774 cooperative agreement from the Department of Health and Human Services' Food and Drug Administration will support the University of California, San Diego in qualifying composite quantitative imaging biomarkers for diagnostic enrichment in nonalcoholic steatohepatitis (NASH) clinical trials. Over the one-year period from September 1, 2022 to August 31, 2023, UC San Diego will prepare and submit a biomarker qualification plan to the FDA's Center for Drug Evaluation and Research...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $250,000 Cooperative Agreement titled "METABOLOMICS WORKBENCH - NATIONAL METABOLOMICS DATA REPOSITORY" to the University of California, San Diego (UCSD). This award, under CFDA Program 93.847 "Diabetes, Digestive, and Kidney Diseases Extramural Research", will fund the continuation and enhancement of the Metabolomics Workbench - National Metabolomics Data Repository (MW-NMDR). The MW-NMDR...

This Project Grant award, valued at $603,736.00 and awarded on July 26, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research), aims to investigate the mechanisms by which the dietary supplement lipoic acid may promote autoimmune dysregulation leading to the development of membranous nephropathy (MN), a rare autoimmune kidney disease. The research will focus on determining whether circulating...

Fred Hutchinson Cancer Center was awarded a $898,342 Project Grant from the Defense Health Agency under the Military Medical Research and Development federal grant program (CFDA 12.420). The grant will fund research from July 1, 2023 to June 30, 2026 to exploit real-world clinical genomic data to discover biomarkers and address outcome disparity for prostate cancer. Through this award, Fred Hutchinson Cancer Center will leverage existing genomic and clinical data to identify biomarkers...

This federal Project Grant award for $892,433.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research aimed at understanding the role of eicosanoids (bioactive lipid molecules) in the development of chronic kidney disease (CKD) and associated cardiovascular risk. The research project, led by the principal investigator at Cedars-Sinai Medical Center,...