Formula Grant R43CK000680

This Project Grant award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) provides $305,000.00 to Primary Bioscience, Inc. to develop an ultra-sensitive biosensor capable of protein analysis at the single-molecule level. The biosensor consists of a nanopatterned chip with a proprietary material that binds and immobilizes molecular targets, which are then detected using surface-enhanced Raman spectroscopy (SERS). This technology aims to enable...

This $275,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program supports the development of a label-free, high-resolution, high-throughput protein screening platform called Vibrational Spectroscopy with Metasurface Optics (VISMO). The technology aims to enable simultaneous, minute-scale measurement of millions of protein samples, which would dramatically improve the lengthy and costly cycles...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $986,651 to Auragent Bioscience LLC (doing business as Brightest Bio) to develop an ultrabright fluorescent reagent called a Plasmonic Fluor (PF). The PF technology is designed to significantly enhance the detection sensitivity of fluorescent Western blot assays, enabling more precise protein concentration measurements and...

The National Science Foundation (NSF) awarded a $650,000 project grant under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to the University of Nevada, Reno to establish a point-of-care (POC) platform technology using smartphone-based time-resolved luminescence imaging and detection (STRIDE) enabled by manganese-doped semiconductor nanocrystals and artificial intelligence. This 1-year project will: (1) further develop the photophysics and optical properties of the...

This $295,308 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will support the development and validation of a novel class of scanning probe microscopy (SPM) probes for rapid identification of infectious disease agents. The awardee, Actoprobe LLC, aims to dramatically improve the sensitivity and spatial resolution of scanning...

This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $295,561 to Biosensing Instrument Inc. to develop a commercial prototype of their Plasmonic Scattering Microscopy (PSM) technology. The PSM system aims to enable high-throughput, label-free quantification of membrane protein binding kinetics on single cells in their native cellular microenvironment. This represents a...

The National Science Foundation (NSF) awarded a $304,966 Small Business Innovation Research (SBIR) Phase I grant to Kompass Diagnostics Inc., a small business located in Chicago, IL. The objective of this 6-month project is to develop a portable, cost-effective, and rapid point-of-care diagnostic device that uses high-sensitivity biosensors to detect multiple blood-based biomarkers, starting with reproductive hormones. The project aims to address capacity constraints in reproductive care, reduce...

This $270,128 SBIR Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) supports the development of a low-cost, field-use DNA-based rapid diagnostic device for detecting plant diseases. The project aims to create a user-friendly, battery-operated testing kit that allows farmers to quickly identify diseases like citrus greening in their fields, enabling early intervention and more sustainable farming practices. The 9-month...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology by Biosensing Instrument Inc. The SFNOA system aims to enable high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The $349,566 award, effective from April 2, 2025 to March 31, 2026,...