Cooperative Agreement W911NF2120074

This federal Project Grant award of $446,126 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a new bioassay to study astrocyte borders and profile their functional states in the context of diverse non-neural cell populations. The key objectives are to optimize the bioassay by combining injectable cellulose-based hydrogels with viral vectors to...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $361,975 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to The Research Foundation For The State University Of New York (doing business as Stony Brook University). This grant will fund the development of a chemical strategy to enable direct visualization and manipulation of astrocytes, the non-neuronal brain cells that play a...

This Project Grant award from the National Institutes of Health (NIH) Office of the Director under CFDA 93.310 - Trans-NIH Research Support program totals $1,490,348 and is aimed at testing an integrative hypothesis about the role of astrocytes in the brain's neuromodulator signaling systems. The award, made to the Research Foundation For Mental Hygiene, Inc. (RFMH) doing business as the New York Psychiatric Center, will utilize state-of-the-art cellular imaging and spatial transcriptomics...

The National Institutes of Health National Institute of Neurological Disorders and Stroke awarded $3.6 million under the 21st Century Cures Act Brain Research through Advancing Innovative Neurotechnologies program (CFDA 93.372) to Stanford University. The project grant will support development of a noninvasive, dynamically programmable in vivo light source for rapid brain-wide optogenetic screening. Specifically, the awardee aims to develop mechanoluminescent nanoparticles with distinct emission...

The Department of the Air Force awarded a $714,960 Project Grant under the Air Force Defense Research Sciences Program (CFDA 12.800) to Consiglio Nazionale Delle Ricerche (CNR), operating as Ipcb-Cnr, a research institution in Italy. The grant funds a 3-year project titled "Modulation of Astrocytes as New Paths to Dialogue with the Brain ASTROTALK" to investigate new means of interacting with the brain through the modulation of astrocytes, specialized brain cells that support neuron...

The University of Illinois has been awarded a $1,870,822 Project Grant from the National Institute on Aging's Aging Research program (CFDA 93.866) to develop new super-resolution fluorescence microscopy techniques. The goal is to achieve ultra-high resolution imaging of native amyloid-alpha receptors (AMPARs) in brain slices to study synaptic plasticity in both healthy and tauopathy conditions. The research will utilize multi-color imaging and digital image reconstruction methods to isolate...

This $500,000 project grant from the National Science Foundation Division of Electrical, Communications and Cyber Systems Engineering program will fund research into magnetoelectric nanoparticles as multi-field controlled devices for wireless brain stimulation. Led by researchers at the University of Miami, the three-year project aims to experimentally study the feasibility of using magnetoelectric nanoparticles to achieve wireless deep brain stimulation with sub-millimeter spatial resolution in...

This NSF Engineering Program award of $605,320 to North Carolina State University (NC State) supports the development of a flexible, FMRI-compatible neural probe with multi-modal sensing and modulation capabilities. The novel probe is designed to advance understanding of neural circuit dynamics and enable closed-loop neuromodulation for treating neurological disorders. Key product elements include: Flexible, multi-shank neural probe fabricated using polymeric materials to enable deep brain...

This $2.8 million project grant from the National Institutes of Health Office of the Director, under the Trans-NIH Research Support program (CFDA 93.310), will fund the development of multifunctional phase sensors to probe and manipulate intracellular biomolecular condensates in brain organoid models. Emory University, as the primary awardee, will engineer sensors encoded with ultra-weak multivalent interactions and fluorescent and catalytic domains to serve as multi-functional liquid-liquid...

This $275,000 project grant from the National Science Foundation's Engineering Directorate (CFDA 47.041) will fund the development of novel electronic-photonic silicon carbide neural probes for recording and stimulating neural activity. The Georgia Tech Research Corporation will receive funding on behalf of collaborating researchers to design penetrating neural probes made entirely of silicon carbide, a robust material proven to withstand the corrosive brain environment long-term. The probes...