Cooperative Agreement W911NF1720012

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), is funding research to better understand the fundamental processes shaping the propagation of Influenza A Viruses (IAVs). The $147,486 grant, awarded on Jun 27, 2025, will support the use of the Influenza A/Netherlands/602/2009 (H1N1) virus to generate viral variants deficient in core early life cycle processes....

This Project Grant award of $239,120 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research by Tufts University School of Medicine to analyze the heterogeneity of cell death responses in influenza virus-infected cells. The objective is to elucidate the interplay between transcriptional and cell death responses to understand which cell death events can be safely targeted therapeutically...

The federal Project Grant award of $734,184.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to elucidate the mechanism of genome replication for non-segmented negative-strand RNA viruses, including paramyxoviruses such as human parainfluenza virus type 3 (HPIV-3). The grant, awarded to Trustees of Boston University Medical Campus, aims to characterize the structure and...

This Cooperative Agreement award of $1,352,292 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports a research project to develop a high-resolution profiling and computational modeling framework for studying influenza virus-immune dynamics during natural infection. The project aims to address critical knowledge gaps in understanding the human immune response to influenza viruses, with the goal...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $147,486.00 to Emory University to develop novel methods for assessing the pandemic potential of influenza A viruses. The project aims to accomplish this through two approaches: 1) using data from animal transmission studies to estimate key epidemiological parameters like the basic reproduction number and...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $438,500.00 in funding to the University of California, San Diego (UCSD) to conduct research on the sequence-specific determinants and impacts of interactions between the influenza A virus (IAV) protein NS2 and the viral polymerase. The research aims to expand upon prior work characterizing the IAV...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to investigate the role of phosphoinositides in influenza virus assembly. The $430,613 award to the University of Maine System will fund a 3-year project to study how the viral surface glycoprotein hemagglutinin and the matrix protein M1 interact with host cell phosphoinositides to facilitate virus cluster formation and...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), through the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $785,511 to the University of Chicago to characterize individual and population-level variability in immune responses to Mycobacterium tuberculosis (TB) and influenza virus infections. The research will leverage induced pluripotent stem cell-derived macrophages to study the genetic and epigenetic factors...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will provide $744,977 to Emory University to explore the role of T cells in protecting against respiratory virus transmission. The research aims to define the cellular interactions and molecular mechanisms that enable tissue-resident memory T cells (TRM) to rapidly identify and eliminate infected cells, thereby limiting virus propagation and...

This $146,922 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at Emory University to study factors modulating the efficiency of influenza A virus (IAV) infection. The researchers will conduct intranasal and aerosol inoculations in guinea pigs to model direct and airborne transmission of IAV, using barcoded viral libraries to assess the intensity of exposure. They will also test...